2019
Promoters to Study Vascular Smooth Muscle
Chakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA. Promoters to Study Vascular Smooth Muscle. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 603-612. PMID: 30727757, PMCID: PMC6527360, DOI: 10.1161/atvbaha.119.312449.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell LineCell LineageCell TransdifferentiationGene Expression RegulationGene Knockout TechniquesGene TargetingHumansMiceMicrofilament ProteinsMuscle ProteinsMuscle, Smooth, VascularMyocytes, Smooth MuscleMyofibroblastsMyosin Heavy ChainsNeovascularization, PathologicNeovascularization, PhysiologicPhenotypePromoter Regions, GeneticRecombinant Fusion ProteinsConceptsSmooth muscle cellsCre driver linesDiversity of phenotypesMuscle cell typesVisceral smooth muscle cellsSMC transdifferentiationActa2 promoterRemarkable plasticityExciting new eraSMC functionCell typesCre linesEmbryonic heartExciting discoveriesPhenotypeMuscle cellsPerivascular adipocytesPromoterVascular smooth muscleNonmuscular cellsExpressionMyeloid cellsCardiovascular phenotypesCellsBlood vessel wall
2006
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
Liu L, Li F, Cardelli J, Martin K, Blenis J, Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 2006, 25: 7029-7040. PMID: 16715128, DOI: 10.1038/sj.onc.1209691.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCattleCell Cycle ProteinsCell LineCell MovementCytoprotectionDown-RegulationEnzyme ActivationHumansInsulin-Like Growth Factor IMicePhosphoproteinsPhosphorylationProtein KinasesRibosomal Protein S6 Kinases, 70-kDaSerumSignal TransductionSirolimusTOR Serine-Threonine KinasesTranscription FactorsConceptsCell motilityRNA interferenceEukaryotic initiation factor 4EDownregulation of RaptorType I insulin-like growth factorMTOR kinase activityInitiation factor 4ES6 kinase 1Rapamycin inhibitionTumor cell motilityResistant mutantsSuppression of mTORP70 S6K1Kinase activityKinase 1S6K1Mammalian targetRapamycinProtein 1Effect of rapamycinConsequence of inhibitionCell linesMutantsRaptorsMotility
1998
The Orphan Seven-Transmembrane Receptor Apj Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human Immunodeficiency Virus Type 1
Choe H, Farzan M, Konkel M, Martin K, Sun Y, Marcon L, Cayabyab M, Berman M, Dorf M, Gerard N, Gerard C, Sodroski J. The Orphan Seven-Transmembrane Receptor Apj Supports the Entry of Primary T-Cell-Line-Tropic and Dualtropic Human Immunodeficiency Virus Type 1. Journal Of Virology 1998, 72: 6113-6118. PMID: 9621075, PMCID: PMC110417, DOI: 10.1128/jvi.72.7.6113-6118.1998.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1T cell line tropicType 1Peripheral blood mononuclear cellsHIV-1 infectionHIV-1 isolatesBlood mononuclear cellsHIV-1 coreceptorsChemokine receptor CCR5Such coreceptorsMononuclear cellsAsymptomatic stageReceptor APJReceptor CCR5HIV-1Infected individualsCoreceptorAPJTarget cellsInfectionReceptorsViral evolutionSIVmac316A Tyrosine-Rich Region in the N Terminus of CCR5 Is Important for Human Immunodeficiency Virus Type 1 Entry and Mediates an Association between gp120 and CCR5
Farzan M, Choe H, Vaca L, Martin K, Sun Y, Desjardins E, Ruffing N, Wu L, Wyatt R, Gerard N, Gerard C, Sodroski J. A Tyrosine-Rich Region in the N Terminus of CCR5 Is Important for Human Immunodeficiency Virus Type 1 Entry and Mediates an Association between gp120 and CCR5. Journal Of Virology 1998, 72: 1160-1164. PMID: 9445013, PMCID: PMC124591, DOI: 10.1128/jvi.72.2.1160-1164.1998.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1CCR5 mutantsHuman immunodeficiency virus type 1 (HIV-1) entryHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus entryDual-tropic variantsSpecific chemokine receptorsChemokine receptor CCR5Macrophage-tropic strainsVirus type 1Region of CCR5Wild-type CCR5Gp120 envelope glycoproteinInfection of cellsMacrophage-tropicAsymptomatic stageChemokine receptorsReceptor CCR5Gp120 glycoproteinCCR5Type 1InfectionEnvelope glycoprotein
1997
CD4-Independent Binding of SIV gp120 to Rhesus CCR5
Martin K, Wyatt R, Farzan M, Choe H, Marcon L, Desjardins E, Robinson J, Sodroski J, Gerard C, Gerard N. CD4-Independent Binding of SIV gp120 to Rhesus CCR5. Science 1997, 278: 1470-1473. PMID: 9367961, DOI: 10.1126/science.278.5342.1470.Peer-Reviewed Original ResearchTwo Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection
Farzan M, Choe H, Martin K, Marcon L, Hofmann W, Karlsson G, Sun Y, Barrett P, Marchand N, Sullivan N, Gerard N, Gerard C, Sodroski J. Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection. Journal Of Experimental Medicine 1997, 186: 405-411. PMID: 9236192, PMCID: PMC2198994, DOI: 10.1084/jem.186.3.405.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD4 AntigensCD4-Positive T-LymphocytesCell LineCloning, MolecularHumansMacaca mulattaMacrophages, AlveolarMolecular Sequence DataReceptors, CCR5Receptors, CytokineReceptors, HIVReceptors, VirusSimian Acquired Immunodeficiency SyndromeSimian immunodeficiency virusConceptsSimian immunodeficiency virusSeven-transmembrane segment receptorsPrimate immunodeficiency virusesImmunodeficiency virusChemokine receptorsMacaque peripheral blood mononuclear cellsRhesus macaque peripheral blood mononuclear cellsSimian immunodeficiency virus (SIV) infectionHuman immunodeficiency virus type 1Peripheral blood mononuclear cellsImmunodeficiency virus type 1Immunodeficiency virus infectionBlood mononuclear cellsHIV-1 variantsChemokine receptor CCR5Central nervous systemCourse of infectionAdditional chemokine receptorsVirus type 1Human alveolar macrophagesMononuclear cellsEntry cofactorReceptor CCR5T lymphocytesVirus infectionHIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*
Farzan M, Choe H, Martin K, Sun Y, Sidelko M, Mackay C, Gerard N, Sodroski J, Gerard C. HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*. Journal Of Biological Chemistry 1997, 272: 6854-6857. PMID: 9054370, DOI: 10.1074/jbc.272.11.6854.Peer-Reviewed Original ResearchConceptsHIV-1 entryInflammatory protein-1betaChemokine receptor CCR5Viral entryReceptor CCR5Macrophage inflammatory protein-1βHuman immunodeficiency virus type 1Immunodeficiency virus type 1Ability of CCR5Only viral entrySpecific chemokine receptorsInflammatory protein-1βMacrophage-tropic strainsVirus type 1Wild-type CCR5CCR5 mutantsMCP-1Asymptomatic stageChemokine receptorsHIV-1CCR5Virus life cycleChemokine signalingType 1Target cellsDown-Regulation of P2U-Purinergic Nucleotide Receptor Messenger RNA Expression During In Vitro Differentiation of Human Myeloid Leukocytes by Phorbol Esters or Inflammatory Activators
Martin K, Kertesy S, Dubyak G. Down-Regulation of P2U-Purinergic Nucleotide Receptor Messenger RNA Expression During In Vitro Differentiation of Human Myeloid Leukocytes by Phorbol Esters or Inflammatory Activators. Molecular Pharmacology 1997, 51: 97-108. PMID: 9016351, DOI: 10.1124/mol.51.1.97.Peer-Reviewed Original ResearchConceptsTHP-1 monocytesHL-60 cellsMRNA levelsMyeloid leukocytesReceptor messenger RNA expressionMonocyte/macrophage phenotypeMessenger RNA expressionInositol phospholipid hydrolysisNeutrophil phenotypeInflammatory activationHL-60 granulocytesUndifferentiated HL-60 cellsInflammatory activatorsInflammatory macrophagesAcute exposureMacrophage phenotypeNucleotide receptorsHuman epithelial cellsTissue-specific mechanismsEpithelial cellsRNA expressionLeukocytesDown regulationDibutyryl cAMPHuman keratinocytes