Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection
Farzan M, Choe H, Martin K, Marcon L, Hofmann W, Karlsson G, Sun Y, Barrett P, Marchand N, Sullivan N, Gerard N, Gerard C, Sodroski J. Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection. Journal Of Experimental Medicine 1997, 186: 405-411. PMID: 9236192, PMCID: PMC2198994, DOI: 10.1084/jem.186.3.405.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD4 AntigensCD4-Positive T-LymphocytesCell LineCloning, MolecularHumansMacaca mulattaMacrophages, AlveolarMolecular Sequence DataReceptors, CCR5Receptors, CytokineReceptors, HIVReceptors, VirusSimian Acquired Immunodeficiency SyndromeSimian immunodeficiency virusConceptsSimian immunodeficiency virusSeven-transmembrane segment receptorsPrimate immunodeficiency virusesImmunodeficiency virusChemokine receptorsMacaque peripheral blood mononuclear cellsRhesus macaque peripheral blood mononuclear cellsSimian immunodeficiency virus (SIV) infectionHuman immunodeficiency virus type 1Peripheral blood mononuclear cellsImmunodeficiency virus type 1Immunodeficiency virus infectionBlood mononuclear cellsHIV-1 variantsChemokine receptor CCR5Central nervous systemCourse of infectionAdditional chemokine receptorsVirus type 1Human alveolar macrophagesMononuclear cellsEntry cofactorReceptor CCR5T lymphocytesVirus infectionUtilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239
Marcon L, Choe H, Martin K, Farzan M, Ponath P, Wu L, Newman W, Gerard N, Gerard C, Sodroski J. Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239. Journal Of Virology 1997, 71: 2522-2527. PMID: 9032394, PMCID: PMC191367, DOI: 10.1128/jvi.71.3.2522-2527.1997.Peer-Reviewed Original ResearchConceptsPathogenic simian immunodeficiency virusSimian immunodeficiency virusImmunodeficiency virusEnvelope glycoproteinPrimary human immunodeficiency virus type 1C chemokine receptor CCR5C chemokine receptor 5Human immunodeficiency virus type 1Immunodeficiency virus type 1SIVmac239 envelope glycoproteinsChemokine receptor 5Infection of CD4Chemokine receptor CCR5Virus type 1Chemokine receptorsEntry cofactorReceptor CCR5Receptor 5Type 1Virus entryCCR5VirusSIVmac239GlycoproteinCell fusion