2006
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
Liu L, Li F, Cardelli J, Martin K, Blenis J, Huang S. Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 2006, 25: 7029-7040. PMID: 16715128, DOI: 10.1038/sj.onc.1209691.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCattleCell Cycle ProteinsCell LineCell MovementCytoprotectionDown-RegulationEnzyme ActivationHumansInsulin-Like Growth Factor IMicePhosphoproteinsPhosphorylationProtein KinasesRibosomal Protein S6 Kinases, 70-kDaSerumSignal TransductionSirolimusTOR Serine-Threonine KinasesTranscription FactorsConceptsCell motilityRNA interferenceEukaryotic initiation factor 4EDownregulation of RaptorType I insulin-like growth factorMTOR kinase activityInitiation factor 4ES6 kinase 1Rapamycin inhibitionTumor cell motilityResistant mutantsSuppression of mTORP70 S6K1Kinase activityKinase 1S6K1Mammalian targetRapamycinProtein 1Effect of rapamycinConsequence of inhibitionCell linesMutantsRaptorsMotility
2000
Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*
Martin K, Schalm S, Romanelli A, Keon K, Blenis J. Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*. Journal Of Biological Chemistry 2000, 276: 7892-7898. PMID: 11108720, DOI: 10.1074/jbc.m009972200.Peer-Reviewed Original ResearchMeSH KeywordsButadienesCells, CulturedEnzyme ActivationEpidermal Growth FactorHumansIsoenzymesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase KinasesMitogen-Activated Protein KinasesNitrilesPhosphatidylinositol 3-KinasesPhosphorylationRibosomal Protein S6 KinasesConceptsNuclear localization signalLocalization signalPhosphorylation sitesProtein kinaseMitogen-activated protein kinase phosphorylation siteC-terminal nuclear localization signalSerine/threonine protein kinaseProtein kinase phosphorylation siteSignal-regulated kinase kinaseRibosomal S6 kinase 2C-terminal phosphorylation sitesC-terminal repressor domainThreonine protein kinaseKinase phosphorylation siteC-terminal motifMitogen-activated protein kinasePhosphorylation site mutationsS6 kinase 2C-terminal domainKinase kinase inhibitor U0126Ribosomal protein S6C-terminal deletionsC-terminal regionKinase inhibitor U0126Site-specific mutations