The Critical Role of Transmembrane Prolines in Human Prostacyclin Receptor Activation
Stitham J, Martin KA, Hwa J. The Critical Role of Transmembrane Prolines in Human Prostacyclin Receptor Activation. Molecular Pharmacology 2002, 61: 1202-1210. PMID: 11961139, DOI: 10.1124/mol.61.5.1202.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsHuman prostacyclin receptorTransmembrane prolinesMolecular hingeProtein-coupled receptorsVascular smooth muscle relaxationProstacyclin receptor activationAlanine mutationsExtracellular boundarySmooth muscle relaxationPro-89Proline residuesLigand bindingGPCR activationExtracellular locationProper bindingWild-type controlsPosition 89ProlineMuscle relaxationPlatelet aggregationReceptor activationProstacyclin receptorCritical roleBinding