Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membrane
Merlin D, Guo X, Martin K, Laboisse C, Landis D, Dubyak G, Hopfer U. Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membrane. American Journal Of Physiology 1996, 271: c612-c619. PMID: 8770002, DOI: 10.1152/ajpcell.1996.271.2.c612.Peer-Reviewed Original ResearchConceptsHT29-ClGranule fusionCl- channelsFungal metabolite wortmanninCAMP-activated Cl- channelMucin granulesCell linesRegulated exocytosisWortmannin concentrationsPlasma membraneActin depolymerizationWortmannin inhibitionCell line HT-29Granule membranesExtracellular ATPEpithelial cellsFusion inhibitorsHuman adenocarcinoma cell line HT-29WortmanninSecretion releaseCl- conductancePhalloidinMembraneDifferential inhibitionHT-29