Intracellular signaling mechanisms associated with CD47 modified surfaces
Finley M, Clark K, Alferiev I, Levy R, Stachelek S. Intracellular signaling mechanisms associated with CD47 modified surfaces. Biomaterials 2013, 34: 8640-8649. PMID: 23948164, PMCID: PMC3804223, DOI: 10.1016/j.biomaterials.2013.07.088.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBloodCD47 AntigenChemokinesCytokinesDown-RegulationFemaleHumansJanus Kinase 2MaleMatrix Metalloproteinase 1Matrix Metalloproteinase 13Matrix Metalloproteinase 7Middle AgedPolyvinyl ChlorideSignal TransductionSTAT Transcription FactorsTranscription, GeneticTranscriptional ActivationUp-RegulationYoung AdultConceptsTranscription factor bindingDifferential molecular responsesJAK/STATChromatin associationCell signaling levelsSynthetic polymeric surfacesTranscriptional changesFactor bindingDownregulation of cytokinesJAK-STATRelated genesUpregulation of MMPsInflammatory cell responseExposure of bloodInflammatory cell interactionsMolecular responseTranscriptionQPCR arrayCell interactionsInflammatory responseHuman whole bloodCell responsesCD47BloodWhole bloodAngina Pectoris or Myocardial Infarctions, Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Paradoxical Emboli
Clark K, Pyeritz R, Trerotola S. Angina Pectoris or Myocardial Infarctions, Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Paradoxical Emboli. The American Journal Of Cardiology 2013, 112: 731-734. PMID: 23707042, DOI: 10.1016/j.amjcard.2013.04.052.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAngina PectorisArteriovenous MalformationsChildChild, PreschoolEmbolism, ParadoxicalEmbolization, TherapeuticFemaleHumansMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaPulmonary ArteryPulmonary VeinsRetrospective StudiesSelf ReportTelangiectasia, Hereditary HemorrhagicYoung AdultConceptsPulmonary arteriovenous malformationsParadoxical emboliHereditary hemorrhagic telangiectasiaCoronary arteryMyocardial infarctionArteriovenous malformationsHemorrhagic telangiectasiaSingle-center populationNormal coronary arteriesTransient ischemic attackCardiac ischemic eventsUntreated pulmonary arteriovenous malformationsSingle artery occlusionAutosomal dominant disorderCardiopulmonary symptomsIschemic attackChest painArtery occlusionIschemic eventsAngina pectorisCardiac catheterizationClinical complicationsVascular malformationsCardiac ischemiaPatients