2015
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM. FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders. Cell 2015, 162: 375-390. PMID: 26186191, PMCID: PMC4519016, DOI: 10.1016/j.cell.2015.06.034.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cellsGene network analysisGene network modulesUpregulation of genesTranscription factor Foxg1Accelerated cell cyclePluripotent stem cellsRNA interferenceGenetic basisSynaptic assemblyCell cycleBrain developmentNeuron fateNeuron differentiationNeuronal differentiationGenomic mutationsHuman brain developmentIdiopathic autism spectrum disorderAltered expressionStem cellsCell proliferationFOXG1ASD pathophysiologyNetwork modulesNeural cultures
2014
Early Generalized Overgrowth in Autism Spectrum Disorder: Prevalence Rates, Gender Effects, and Clinical Outcomes
Campbell DJ, Chang J, Chawarska K. Early Generalized Overgrowth in Autism Spectrum Disorder: Prevalence Rates, Gender Effects, and Clinical Outcomes. Journal Of The American Academy Of Child & Adolescent Psychiatry 2014, 53: 1063-1073.e5. PMID: 25245350, PMCID: PMC4173120, DOI: 10.1016/j.jaac.2014.07.008.Peer-Reviewed Original ResearchConceptsClinical outcomesGeneralized overgrowthEarly growth abnormalitiesAutism spectrum disorderCommunity controlsEarly postnatal periodYears of ageAtypical brain developmentHead circumferencePostnatal periodPrevalence ratesSpectrum disorderEarly overgrowthSymptom severityBrain developmentPostnatal overgrowthSomatic overgrowthGrowth abnormalitiesOptimal outcomesBody overgrowthGender effectsOutcomesEarly headAbnormalitiesPrevalence