2014
Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2
Bihuniak JD, Sullivan RR, Simpson CA, Caseria DM, Huedo-Medina TB, O’Brien K, Kerstetter JE, Insogna KL. Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2. Journal Of Nutrition 2014, 144: 282-288. PMID: 24431325, PMCID: PMC3927545, DOI: 10.3945/jn.113.185009.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionLow-protein dietCalcium absorptionDual-stable calcium isotopesYoung womenUrinary calcium excretionDietary proteinControl diet periodAmino acid L-arginineHigh-protein dietAmino acid L-tryptophanCalcium excretionDiet periodClinical trialsSupplementation periodL-arginineDay 5Control dietRandom orderPhysiologic rangeDietTrialsWomenPossible benefitsL-tryptophan
2013
Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats
Thomas CE, Gaffney‐Stomberg E, Sun B, O'Brien KO, Kerstetter JE, Insogna KL. Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats. The FASEB Journal 2013, 27: 2476-2483. PMID: 23447582, DOI: 10.1096/fj.12-221945.Peer-Reviewed Original ResearchConceptsIntestinal Fe absorptionDietary proteinFe absorptionIron transporter expressionTranscript expressionDuodenal mucosaAcute effectsSprague-DawleyStable iron isotopesIron absorptionShort-term effectsIsocaloric dietsIron deficiencyTransporter expressionLittle dataTransferrin receptorExpression of genesSeparate studiesGroupCurrent studyBalance studiesExpressionWhole genome profilingDawleyMucosa
2010
Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial
Wright MJ, Sullivan RR, Gaffney‐Stomberg E, Caseria DM, O'Brien KO, Proctor DD, Simpson CA, Kerstetter JE, Insogna KL. Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial. Journal Of Bone And Mineral Research 2010, 25: 2205-2211. PMID: 20499372, PMCID: PMC3312746, DOI: 10.1002/jbmr.108.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalciumCross-Over StudiesDouble-Blind MethodFemaleGastric AcidHumansIntestinal AbsorptionMalePlacebosConceptsIntestinal calcium absorptionProton pump inhibitorsCalcium absorptionGastric acidDual-stable calcium isotopesYoung adultsChronic PPI therapyPotent gastric acidGastric acid suppressionNegative calcium balanceGastric acid productionHealthy young adultsPPI esomeprazolePPI therapyPlacebo groupUrinary calciumAcid suppressionCrossover studyBone lossPump inhibitorsClinical trialsIntervention periodAcute effectsCalcium balanceHealthy individualsThe Effect of Dietary Protein on Intestinal Calcium Absorption in Rats
Gaffney-Stomberg E, Sun BH, Cucchi CE, Simpson CA, Gundberg C, Kerstetter JE, Insogna KL. The Effect of Dietary Protein on Intestinal Calcium Absorption in Rats. Endocrinology 2010, 151: 1071-1078. PMID: 20147526, PMCID: PMC2840679, DOI: 10.1210/en.2009-0744.Peer-Reviewed Original ResearchConceptsIntestinal Ca absorptionCa absorptionHigh-protein dietUrinary calciumBrush border membrane vesiclesProtein intakeFemale Sprague-Dawley ratsProtein dietProtein intake resultsIntestinal calcium absorptionDietary protein intakeHigh protein intakeSprague-Dawley ratsLow-protein groupHigh protein groupDietary protein effectsCalcium absorptionAcute increaseDawley ratsDuodenal mucosaIntake resultsRatsCa balanceTranscellular CaDietary protein
2009
The Effect of Proton Pump-Inhibiting Drugs on Mineral Metabolism
Insogna KL. The Effect of Proton Pump-Inhibiting Drugs on Mineral Metabolism. The American Journal Of Gastroenterology 2009, 104: ajg200944. PMID: 19262542, DOI: 10.1038/ajg.2009.44.BooksMeSH KeywordsAnti-Ulcer AgentsBone and BonesBone DensityCalciumFractures, SpontaneousHip FracturesHumansIntestinal AbsorptionOsteoporosisProton Pump InhibitorsConceptsProton pump inhibitorsMineral metabolismLong-term proton pump inhibitorsIntestinal calcium absorptionHip fracture ratesClass of drugsFragility fracturesBone lossCalcium economyPump inhibitorsCalcium absorptionFracture ratesCalcium balanceSkeletal homeostasisGreater riskAdverse effectsHigh rateDrugsRecent studiesMetabolismLong term
2004
The Impact of Dietary Protein on Calcium Absorption and Kinetic Measures of Bone Turnover in Women
Kerstetter JE, O’Brien K, Caseria DM, Wall DE, Insogna KL. The Impact of Dietary Protein on Calcium Absorption and Kinetic Measures of Bone Turnover in Women. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 26-31. PMID: 15546911, DOI: 10.1210/jc.2004-0179.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone ResorptionCalciumDietary ProteinsFemaleHumansIntestinal AbsorptionKineticsOsteogenesisConceptsHigh-protein dietUrinary calciumBone turnoverCalcium absorptionDual-stable calcium isotopesAdditional urinary calciumIntestinal calcium absorptionHealthy womenStable calcium isotopesBone balanceNonsignificant trendSkeletal resorptionCalcium kineticsAcid loadBone originProtein-induced effectsLevels of proteinRandom orderDietary proteinDietHypercalciuriaWomenExperimental dietsSignificant reductionCalcium
2003
Low Protein Intake: The Impact on Calcium and Bone Homeostasis in Humans
Kerstetter JE, O'Brien KO, Insogna KL. Low Protein Intake: The Impact on Calcium and Bone Homeostasis in Humans. Journal Of Nutrition 2003, 133: 855s-861s. PMID: 12612169, DOI: 10.1093/jn/133.3.855s.BooksConceptsIntestinal calcium absorptionLow-protein dietCalcium absorptionHigh-protein dietProtein dietSecondary hyperparathyroidismUrinary calciumBone resorptionDietary proteinAdditional urinary calciumDietary protein resultsSerum parathyroid hormoneNutrition intervention trialCalcium balance studiesRecent epidemiological studiesLow protein intakeNutrition intervention studiesParathyroid hormoneBone lossSkeletal healthIntervention trialsCalcium metabolismSkeletal fracturesBone densityLong-term consequences
2001
Dietary protein and intestinal calcium absorption
Kerstetter J, O’Brien K, Insogna K. Dietary protein and intestinal calcium absorption. American Journal Of Clinical Nutrition 2001, 73: 990-991. PMID: 11333855, DOI: 10.1093/ajcn/73.5.990.Peer-Reviewed Original Research
2000
A threshold for low-protein-diet–induced elevations in parathyroid hormone 1 , 2 , 3
Kerstetter J, Svastisalee C, Caseria D, Mitnick M, Insogna K. A threshold for low-protein-diet–induced elevations in parathyroid hormone 1 , 2 , 3. American Journal Of Clinical Nutrition 2000, 72: 168-173. PMID: 10871576, DOI: 10.1093/ajcn/72.1.168.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalciumDiet, Protein-RestrictedDietary ProteinsFemaleHomeostasisHumansIntestinal AbsorptionNutritional RequirementsParathyroid HormoneConceptsYoung healthy womenParathyroid hormoneHealthy womenCalcium homeostasisDay 4Nephrogenous cyclic adenosine monophosphateDiet-induced elevationIntestinal calcium absorptionBody mass indexDietary proteinDietary protein intakeParathyroid hormone 1Protein/Urinary calciumCalcitropic hormonesMass indexCalcium absorptionPerturb calcium homeostasisMean 24Normal rangeAverage ageProtein intakeDietary allowanceCyclic adenosine monophosphateHormone 1
1998
Dietary protein affects intestinal calcium absorption 1 , 2 – 3
Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein affects intestinal calcium absorption 1 , 2 – 3. American Journal Of Clinical Nutrition 1998, 68: 859-865. PMID: 9771863, DOI: 10.1093/ajcn/68.4.859.Peer-Reviewed Original ResearchConceptsFractional calcium absorptionLow-protein dietUrinary calcium excretionCalcium absorptionDay 4Calcium excretionSecondary hyperparathyroidismDietary proteinDual-stable calcium isotopesGlomerular filtration rateIntestinal calcium absorptionHigh-protein dietCalcitropic hormonesCalcium metabolismAdditional womenFiltration rateIntestinal absorptionDay 5Young womenRandom orderDietHyperparathyroidismExperimental dietsDietary fiberExcretion
1985
Elevated Production Rate of 1,25-Dihydroxyvitamin D in Patients with Absorptive Hypercalciuria*
INSOGNA K, BROADUS A, DREYER B, ELLISON A, GERTNER J. Elevated Production Rate of 1,25-Dihydroxyvitamin D in Patients with Absorptive Hypercalciuria*. The Journal Of Clinical Endocrinology & Metabolism 1985, 61: 490-495. PMID: 2991323, DOI: 10.1210/jcem-61-3-490.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalcitriolCalciumCyclic AMPFemaleHumansIntestinal AbsorptionKineticsMaleMetabolic Clearance RateMiddle AgedParathyroid HormonePhosphorusConceptsAbsorptive hypercalciuriaMicrograms/dayNormal subjectsMetabolic clearancePlasma radioactivityMean steady-state concentrationMCR valuesHypercalciuric patientsCalcium intakeDihydroxyvitamin DSerial measurementsHypercalciuriaPatientsConstant infusionConflicting resultsClearanceSteady-state concentrations