2009
Dominant role of CD47–thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease
Kukreja A, Radfar S, Sun BH, Insogna K, Dhodapkar MV. Dominant role of CD47–thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease. Blood 2009, 114: 3413-3421. PMID: 19661269, PMCID: PMC2765677, DOI: 10.1182/blood-2009-03-211920.Peer-Reviewed Original ResearchConceptsHuman dendritic cellsDendritic cellsBone diseaseOsteoclast formationRecruitment of DCsTumor cellsThrombospondin-1Regulation of CD47Tumor-associated osteoclastsNuclear factor-kappaB ligandMyeloma bone diseaseLytic bone diseasePrimary myeloma cellsHuman osteoclast formationMyeloma cell linesParathyroid hormoneKappaB ligandReceptor activatorOsteoclast precursorsGiant cellsSpontaneous cell-cell fusionMyeloma cellsHuman monocytesMyeloma tumorsDisease
2004
Fibroblast Growth Factor 7: An Inhibitor of Phosphate Transport Derived from Oncogenic Osteomalacia-Causing Tumors
Carpenter TO, Ellis BK, Insogna KL, Philbrick WM, Sterpka J, Shimkets R. Fibroblast Growth Factor 7: An Inhibitor of Phosphate Transport Derived from Oncogenic Osteomalacia-Causing Tumors. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1012-1020. PMID: 15562028, DOI: 10.1210/jc.2004-0357.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone NeoplasmsCD4 AntigensCell Line, TumorChildCulture Media, ConditionedFibroblast Growth Factor 7Fibroblast Growth Factor-23Fibroblast Growth FactorsGene Expression RegulationHumansInsulin-Like Growth Factor Binding Protein 4KineticsMaleMiddle AgedOsteomalaciaPhosphate Transport ProteinsConceptsFibroblast growth factor 7Tumor-derived culturesOncogenic osteomalaciaInhibitory activityRenal tubular epithelial cellsTubular epithelial cellsRenal phosphate transportPhosphate transportGrowth factor 7Tumor cell culturesRenal phosphate homeostasisNonconditioned mediumTumorsMonoclonal antibodiesEpithelial cellsDirect inhibitorFactor 7Phosphate homeostasisFGF familySyndromeCandidate mRNAsPotent inhibitorInhibitorsTransport inhibitionInhibitory