2018
Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps
Hsieh E, Wang Q, Zhang R, Niu X, Xia W, Fraenkel L, Insogna KL, Li J, Smith JS, Zhou C, Qiao YL, Zhang P. Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps. BMC Cancer 2018, 18: 104. PMID: 29378534, PMCID: PMC5789645, DOI: 10.1186/s12885-018-4014-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsVertebral fracturesCancer survivorsCross-sectional studyBreast cancerBone lossCancer treatment-induced bone lossHealthy community-dwelling postmenopausal womenProgesterone receptor-positive breast cancerHealth servicesBreast cancer survivor cohortCommunity-dwelling postmenopausal womenFracture-related risk factorsPeking Vertebral Fracture StudyTreatment-induced bone lossReceptor-positive breast cancerChinese breast cancer survivorsCancer survivor cohortLarge cancer hospitalThoracolumbar X-rayVitamin D supplementsPrevalent vertebral fracturesBone density scanInitiation of treatmentAdjusted odds ratio
2016
Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy
Knobf MT, Jeon S, Smith B, Harris L, Kerstetter J, Thompson AS, Insogna K. Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy. Breast Cancer Research And Treatment 2016, 155: 491-500. PMID: 26850265, DOI: 10.1007/s10549-016-3693-3.Peer-Reviewed Original ResearchConceptsFemale cancer survivorsPhysical activity groupEndocrine therapyBone outcomesExercise interventionBone lossFemoral neckAromatase inhibitorsActivity groupAdjuvant AI therapyChemotherapy-induced menopauseSufficient serum levelsAdjuvant endocrine therapyVitamin D supplementsHealthy postmenopausal womenLess bone lossHome-based groupSignificant BMD lossSignificant clinical problemMajority of subjectsAI therapyD supplementsPostmenopausal womenBMD lossBMD outcomes
2008
An Aerobic Weight-Loaded Pilot Exercise Intervention for Breast Cancer Survivors: Bone Remodeling and Body Composition Outcomes
Knobf MT, Insogna K, DiPietro L, Fennie K, Thompson AS. An Aerobic Weight-Loaded Pilot Exercise Intervention for Breast Cancer Survivors: Bone Remodeling and Body Composition Outcomes. Biological Research For Nursing 2008, 10: 34-43. PMID: 18705153, PMCID: PMC3540790, DOI: 10.1177/1099800408320579.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAnalysis of VarianceBody CompositionBody WeightBone ResorptionBreast NeoplasmsClinical Nursing ResearchCollagen Type IExerciseExercise TherapyFeasibility StudiesFemaleHumansMiddle AgedObesityOsteocalcinPerimenopausePilot ProjectsSurvivorsTime FactorsTreatment OutcomeWeight LiftingConceptsBreast cancer survivorsExercise interventionCancer survivorsBone remodelingBone lossFat massBody compositionTreadmill 3 times/weekDual-energy absorptiometry scansWeight gainNovel exercise interventionPilot exercise interventionYears of menopauseAdjuvant endocrine therapyBody composition outcomesOne-group pre-posttest designTimes/weekSerum NTxEndocrine therapySerum osteocalcinMean ageSerum biomarkersBone massHigh adherenceHigh risk
1996
Boning up on estrogen: new options, new concerns.
Insogna K, Concato J, Henrich J. Boning up on estrogen: new options, new concerns. JAMA 1996, 276: 1430-2. PMID: 8892721, DOI: 10.1001/jama.276.17.1430.Peer-Reviewed Case Reports and Technical Notes
1987
Skin-Derived Fibroblasts Respond to Human Parathyroid Hormone-Like Adenylate Cyclase-Stimulating Proteins*
WU T, INSOGNA K, HOUGH L, MILSTONE L, STEWART A. Skin-Derived Fibroblasts Respond to Human Parathyroid Hormone-Like Adenylate Cyclase-Stimulating Proteins*. The Journal Of Clinical Endocrinology & Metabolism 1987, 65: 105-109. PMID: 3034948, DOI: 10.1210/jcem-65-1-105.Peer-Reviewed Original ResearchConceptsPTH-like factorHumoral hypercalcemiaPTH analogsPTH-responsive adenylate cyclaseDermal fibroblast linesAdenylate cyclaseTumor-derived factorsAdenylate cyclase responseDermal fibroblastsAdenylate cyclase stimulationHuman dermal fibroblastsM bovine PTHDermal physiologyFibroblast linesHuman dermal fibroblast linesBovine PTHHigh prevalenceTumor extractsCyclase responseSkin-derived fibroblastsCyclase stimulationPTHKeratinocyte-conditioned mediumHuman tumorsApparent potencyIdentification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. Journal Of Biological Chemistry 1987, 262: 7151-7156. PMID: 3584110, DOI: 10.1016/s0021-9258(18)48217-8.Peer-Reviewed Original Research