2016
Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy
Knobf MT, Jeon S, Smith B, Harris L, Kerstetter J, Thompson AS, Insogna K. Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy. Breast Cancer Research And Treatment 2016, 155: 491-500. PMID: 26850265, DOI: 10.1007/s10549-016-3693-3.Peer-Reviewed Original ResearchConceptsFemale cancer survivorsPhysical activity groupEndocrine therapyBone outcomesExercise interventionBone lossFemoral neckAromatase inhibitorsActivity groupAdjuvant AI therapyChemotherapy-induced menopauseSufficient serum levelsAdjuvant endocrine therapyVitamin D supplementsHealthy postmenopausal womenLess bone lossHome-based groupSignificant BMD lossSignificant clinical problemMajority of subjectsAI therapyD supplementsPostmenopausal womenBMD lossBMD outcomes
2015
The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults
Kerstetter JE, Bihuniak JD, Brindisi J, Sullivan RR, Mangano KM, Larocque S, Kotler BM, Simpson CA, Cusano A, Gaffney-Stomberg E, Kleppinger A, Reynolds J, Dziura J, Kenny AM, Insogna KL. The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: 2214-2222. PMID: 25844619, PMCID: PMC4454800, DOI: 10.1210/jc.2014-3792.Peer-Reviewed Original ResearchConceptsBone mineral densityBone resorptionL-spine bone mineral densitySelf-reported protein intakeDual-energy X-ray absorptiometryTruncal lean massPlacebo-controlled trialGlomerular filtration rateBody mass indexProtein supplementationC-terminal telopeptideX-ray absorptiometryFat-free massWhey protein supplementHigh-protein dietHealthy older adultsOlder Caucasian adultsUrine calciumRenal functionMass indexSkeletal healthUsual dietFiltration rateMineral densityBone mass
2014
Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2
Bihuniak JD, Sullivan RR, Simpson CA, Caseria DM, Huedo-Medina TB, O’Brien K, Kerstetter JE, Insogna KL. Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2. Journal Of Nutrition 2014, 144: 282-288. PMID: 24431325, PMCID: PMC3927545, DOI: 10.3945/jn.113.185009.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionLow-protein dietCalcium absorptionDual-stable calcium isotopesYoung womenUrinary calcium excretionDietary proteinControl diet periodAmino acid L-arginineHigh-protein dietAmino acid L-tryptophanCalcium excretionDiet periodClinical trialsSupplementation periodL-arginineDay 5Control dietRandom orderPhysiologic rangeDietTrialsWomenPossible benefitsL-tryptophan
2013
An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey years 2005–2008
Mangano KM, Kerstetter JE, Kenny AM, Insogna KL, Walsh SJ. An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey years 2005–2008. Osteoporosis International 2013, 25: 1033-1041. PMID: 24121998, PMCID: PMC3969769, DOI: 10.1007/s00198-013-2501-8.Peer-Reviewed Original ResearchConceptsSpine bone mineral densityLumbar spine bone mineral densityBone mineral densityTotal femur bone mineral densityFemoral neck bone mineral densityFemur bone mineral densityNeck bone mineral densityFA supplement useSupplement useMineral densityFemoral neckNational HealthOlder adultsDietary omega-3 fatty acid intakeGreater femoral neck BMDHigher spine bone mineral densityHigher lumbar spine bone mineral densityOmega-3 fatty acid intakeDietary omega 3 FAHip bone mineral densityOmega-3 intakeFatty acid intakeNutrition Examination SurveyOmega-3 FAMultivariable regression modelsDietary Acid Load Is Associated With Lower Bone Mineral Density in Men With Low Intake of Dietary Calcium
Mangano KM, Walsh SJ, Kenny AM, Insogna KL, Kerstetter JE. Dietary Acid Load Is Associated With Lower Bone Mineral Density in Men With Low Intake of Dietary Calcium. Journal Of Bone And Mineral Research 2013, 29: 500-506. PMID: 23873776, PMCID: PMC3946957, DOI: 10.1002/jbmr.2053.Peer-Reviewed Original ResearchMeSH KeywordsAcidsAgedBone DensityCalciumCalcium, DietaryDietary SupplementsFemaleFemur HeadHumansLumbar VertebraeMaleMiddle AgedRetrospective StudiesConceptsPotential renal acid loadNet endogenous acid productionProximal femur bone mineral densityDietary acid loadFemur bone mineral densityBone mineral densityCalcium intakeDietary calciumAcid loadMineral densitySupplemental calciumHigh dietary acid loadNutrition Examination Survey 2005Low bone mineral densityMean bone mineral densityLow calcium intakeRenal acid loadLow dietary calciumEndogenous acid productionBone healthBMD sitesMean ageInverse associationNational HealthLow intake
2011
Calcium Intake in the United States from Dietary and Supplemental Sources across Adult Age Groups: New Estimates from the National Health and Nutrition Examination Survey 2003-2006
Mangano KM, Walsh SJ, Insogna KL, Kenny AM, Kerstetter JE. Calcium Intake in the United States from Dietary and Supplemental Sources across Adult Age Groups: New Estimates from the National Health and Nutrition Examination Survey 2003-2006. Journal Of The Academy Of Nutrition And Dietetics 2011, 111: 687-695. PMID: 21515114, PMCID: PMC3896234, DOI: 10.1016/j.jada.2011.02.014.Peer-Reviewed Original ResearchConceptsDietary calcium intakeCalcium intakeCalcium supplement useSupplement useAdult age groupsNational HealthAge groupsCalcium densityEnergy intakeNutrition Examination Survey respondentsTotal calciumNutrition Examination Survey 2003Nutrition Examination Survey dataAdequate intake standardsSupplemental calcium useMedian energy intakeAge 50 yearsYears age groupRecent National HealthOlder age groupsEnergy intake ratioAge-associated changesCross-sectional analysisBone healthDietary calcium