1988
Isolation of 16,000-Dalton Parathyroid Hormone-Like Proteins from Two Animal Tumors Causing Humoral Hypercalcemia of Malignancy*
Weir EC, Burtis WJ, Morris CA, Brady TG, Insogna KL. Isolation of 16,000-Dalton Parathyroid Hormone-Like Proteins from Two Animal Tumors Causing Humoral Hypercalcemia of Malignancy*. Endocrinology 1988, 123: 2744-2751. PMID: 3197642, DOI: 10.1210/endo-123-6-2744.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAmino Acid SequenceAmino AcidsAnimalsDogsHumansHypercalcemiaLeydig Cell TumorMaleMolecular Sequence DataMolecular WeightNeoplasm ProteinsNeoplasmsParathyroid Hormone-Related ProteinRatsRats, Inbred F344Sequence Homology, Nucleic AcidSweat Gland NeoplasmsTesticular NeoplasmsConceptsPTH-like proteinAnimal tumorsPTH-like peptideHumoral hypercalcemiaParathyroid hormone-like proteinSynthetic human PTHLeydig cell tumorHuman PTH-like peptideHormone-like proteinTransplantable animal tumorsCell adenocarcinomaCanine proteinCell tumorsResponsible mediatorsHuman PTHImmunoradiometric assayTumorsHuman tumorsAdenylate cyclaseLike peptidesAnal sacHypercalcemiaBone cellsMalignancyPotent activatorAdenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac
Weir E, Centrella M, Matus R, Brooks M, Wu T, Insogna K. Adenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac. Calcified Tissue International 1988, 43: 359-365. PMID: 3146425, DOI: 10.1007/bf02553279.Peer-Reviewed Original ResearchConceptsAdenylate cyclase-stimulating activityBone-resorbing activityTGF-like activityControl tumorsCell adenocarcinomaAnal sacDose-response curve parallelCyclase-stimulating activityC18 reverse-phase high-pressure liquid chromatographyResponsible mediatorsTumor extractsHigh-pressure liquid chromatographyReverse-phase high-pressure liquid chromatographyTumorsPressure liquid chromatographyAdenocarcinomaC18 RP-HPLCCurve parallelSacExtractHypercalcemiaLiquid chromatographyBPTHActivityResorption
1987
CO-PURIFICATION OF TRANSFORMING GROWTH FACTOR LIKE ACTIVITY WITH PTH-LIKE AND BONE-RESORBING ACTIVITIES FROM A TUMOR ASSOCIATED WITH HUMORAL HYPERCALCEMIA OF MALIGNANCY
INSOGNA K, WEIR E, WU T, STEWART A, BROADUS A, BURTIS W, CENTRELLA M. CO-PURIFICATION OF TRANSFORMING GROWTH FACTOR LIKE ACTIVITY WITH PTH-LIKE AND BONE-RESORBING ACTIVITIES FROM A TUMOR ASSOCIATED WITH HUMORAL HYPERCALCEMIA OF MALIGNANCY. Endocrinology 1987, 120: 2183-2185. PMID: 3494596, DOI: 10.1210/endo-120-5-2183.Peer-Reviewed Original ResearchConceptsAdenylate cyclase-stimulating activityBone-resorbing factorsBone-resorbing activityHumoral hypercalcemiaGrowth factor beta-like activityPTH-like proteinLeydig cell tumorReverse-phase HPLC stepsBeta-like activityCyclase-stimulating activityGrowth factor betaCell tumorsResponsible mediatorsGrowth factor activityTumor extractsFisher ratsAnimal modelsFactor betaTumor tissueSingle fractionGrowth factorHypercalcemiaMalignancyPTHSequential treatment