A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo
Grey A, Mitnick M, Masiukiewicz U, Sun B, Rudikoff S, Jilka R, Manolagas S, Insogna K. A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo. Endocrinology 1999, 140: 4683-4690. PMID: 10499526, DOI: 10.1210/endo.140.10.7036.Peer-Reviewed Original ResearchConceptsParathyroid hormoneInterleukin-6Bone resorptionBiochemical markersPTH infusionEffect of PTHIL-6 productionCytokine interleukin-6Bone-resorbing cellsRelease of calciumPrimary hyperparathyroidismSerum levelsOsteoblastic cellsParacrine agentsCalcium homeostasisExperimental animalsPermissive roleChronic deficiencyResorptionImportant mediatorSystemic levelsBone formationRegulatory effectsInfusionMarkersA Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo1
Grey A, Mitnick M, Masiukiewicz U, Sun B, Rudikoff S, Jilka R, Manolagas S, Insogna K. A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo1. Endocrinology 1999, 140: 4683-4690. DOI: 10.1210/en.140.10.4683.Peer-Reviewed Original ResearchBiochemical markers of bone resorptionMarkers of bone resorptionPTH-induced bone resorptionParathyroid hormoneBone resorptionInterleukin-6Biochemical markersPTH infusionResponse to PTH infusionCirculating levels of interleukin-6Action of PTH in vivoMarkers of bone formationResponse to PTHEffect of parathyroid hormoneLevels of interleukin-6Neutralization of interleukin-6Associated with markedly lower levelsParathyroid hormone-induced bone resorptionPTH in vivoBone resorbing actionPTH-induced changesRelease of calciumInterleukin-6 productionCytokine interleukin-6Paracrine factor(s