1996
24,25 Dihydroxyvitamin D supplementation corrects hyperparathyroidism and improves skeletal abnormalities in X-linked hypophosphatemic rickets--a clinical research center study
Carpenter TO, Keller M, Schwartz D, Mitnick M, Smith C, Ellison A, Carey D, Comite F, Horst R, Travers R, Glorieux FH, Gundberg CM, Poole AR, Insogna KL. 24,25 Dihydroxyvitamin D supplementation corrects hyperparathyroidism and improves skeletal abnormalities in X-linked hypophosphatemic rickets--a clinical research center study. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 2381-2388. PMID: 8964881, DOI: 10.1210/jcem.81.6.8964881.Peer-Reviewed Original ResearchConceptsD3 supplementationStandard treatmentSkeletal lesionsClinical research center studyCorrection of hyperparathyroidismImprovement of ricketsPlacebo-controlled trialD supplementationRachitic abnormalitiesNephrogenous cAMPPTH secretionStandard therapyPTH valuesSerum phosphorusCenter studyRadiographic featuresBone biopsyOsteoid surfaceBone diseaseMurine modelHypophosphatemic ricketsUseful adjunctCalcium homeostasisHyperparathyroidismXLH
1984
Biochemical and Histomorphometric Characterization of a Rat Model for Humoral Hypercalcemia of Malignancy*
INSOGNA K, STEWART A, VIGNERY A, WEIR E, NAMNUM P, BARON R, KIRKWOOD J, DEFTOS L, BROADUS A. Biochemical and Histomorphometric Characterization of a Rat Model for Humoral Hypercalcemia of Malignancy*. Endocrinology 1984, 114: 888-896. PMID: 6546543, DOI: 10.1210/endo-114-3-888.Peer-Reviewed Original ResearchConceptsTumor-bearing animalsBone-resorbing activityHumoral hypercalcemiaDay 13Dihydroxyvitamin D valuesFractional phosphorus excretionQuantitative bone histomorphometryAction of PTHImmunoreactive PTH levelsTumor-bearing groupLeydig cell tumorMale Fisher ratsBone cell functionPTH levelsNephrogenous cAMPDihydroxyvitamin DTumor transplantationCell tumorsBone resorptionBone histomorphometryRat modelTumor groupControl animalsFisher ratsMarked suppressionA Consideration of the Hormonal Basis and Phosphate Leak Hypothesis of Absorptive Hypercalciuria*
BROADUS A, INSOGNA K, LANG R, MALLETTE L, ORENLANG D, GERTNER J, KLIGER A, ELLISON A. A Consideration of the Hormonal Basis and Phosphate Leak Hypothesis of Absorptive Hypercalciuria*. The Journal Of Clinical Endocrinology & Metabolism 1984, 58: 161-169. PMID: 6546292, DOI: 10.1210/jcem-58-1-161.Peer-Reviewed Original ResearchConceptsAbsorptive hypercalciuriaNormal subjectsCalcium excretionOral calcium tolerance testCalcium tolerance testFractional calcium excretionRenal calcium leakRenal phosphate thresholdHypercalciuric patientsMild hypercalcemiaNephrogenous cAMPCalcium intakeDihydroxyvitamin DPathophysiological basisTolerance testPlasma concentrationsUrine collectionStone diseaseCalcium leakPatientsControl groupSevere patternSignificant negative correlationHormonal basisFindings 1
1981
Effect of Age on Serum Immunoreactive Parathyroid Hormone and Its Biological Effects*
INSOGNA K, LEWIS A, LIPINSKI B, BRYANT C, BARAN D. Effect of Age on Serum Immunoreactive Parathyroid Hormone and Its Biological Effects*. The Journal Of Clinical Endocrinology & Metabolism 1981, 53: 1072-1075. PMID: 6270181, DOI: 10.1210/jcem-53-5-1072.Peer-Reviewed Original ResearchConceptsIPTH levelsElderly subjectsTubular maximum phosphate reabsorptionImmunoreactive parathyroid hormone levelsSerum immunoreactive parathyroid hormoneImmunoreactive parathyroid hormoneParathyroid hormone levelsBiological effectsCreatinine clearanceEffect of ageNephrogenous cAMPUrinary calciumCreatinine ratioSerum phosphateParathyroid hormoneBone lossCalcium ingestionBone resorptionPhosphate reabsorptionHormone levelsHealthy volunteersSignificant negative correlationSignificant positive correlationIPTHOlder volunteers