1999
Bone Densities in Patients Receiving Isotretinoin for Cystic Acne
Leachman SA, Insogna KL, Katz L, Ellison A, Milstone LM. Bone Densities in Patients Receiving Isotretinoin for Cystic Acne. JAMA Dermatology 1999, 135: 961-965. PMID: 10456346, DOI: 10.1001/archderm.135.8.961.Peer-Reviewed Original ResearchConceptsCystic acneBone densityWard's triangleCalcium metabolismHealthy control subjectsYoung menIsotretinoin useOral isotretinoinPatient groupControl subjectsMean changeHealthy volunteersControl groupAcnePatientsMeasurable alterationsIsotretinoinFurther studiesOsteoporosisDecreased densityRetinoidsMetabolismMenBoneDirect effect
1992
Cross-cultural association between dietary animal protein and hip fracture: A hypothesis
Abelow B, Holford T, Insogna K. Cross-cultural association between dietary animal protein and hip fracture: A hypothesis. Calcified Tissue International 1992, 50: 14-18. PMID: 1739864, DOI: 10.1007/bf00297291.Peer-Reviewed Original ResearchConceptsHip fracture incidenceFracture incidenceDietary animal proteinHigh animal protein dietTotal caloric intakeAnimal protein dietHip fractureDietary calciumFracture ratesCaloric intakeBone bufferingFracture associationMetabolic acid productionBone dissolutionProtein dietFurther studiesPositive associationProtein consumptionAnimal proteinIncidenceAssociationAnimal protein consumptionRecent studies
1983
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy.
Stewart AF, Insogna KL, Goltzman D, Broadus AE. Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 1454-1458. PMID: 6298791, PMCID: PMC393616, DOI: 10.1073/pnas.80.5.1454.Peer-Reviewed Original ResearchConceptsAdenylate cyclase-stimulating activityCyclase-stimulating activityExtracts of tumorsHumoral hypercalcemiaPTH receptorTumor extractsPTH-sensitive adenylate cyclaseAdenylate cyclaseSensitive cytochemical bioassayRenal PTH receptorsParathyroid hormoneClinical studiesPTH resultsCompetitive inhibition studiesCytochemical bioassayTumorsPatientsHypercalcemiaGlucose-6-phosphate dehydrogenaseHHMFurther studiesMalignancyPTHFragment analogSpecific binding
1980
Osteomalacia and Weakness From Excessive Antacid Ingestion
Insogna K, Bordley D, Caro J, Lockwood D. Osteomalacia and Weakness From Excessive Antacid Ingestion. JAMA 1980, 244: 2544-2546. PMID: 7431592, DOI: 10.1001/jama.1980.03310220042025.Peer-Reviewed Original ResearchConceptsAluminum hydroxide-containing antacidElevated alkaline phosphatase levelsSerum calcium levelsAlkaline phosphatase levelsAntacid ingestionBone painPhosphate malabsorptionSevere hypophosphatemiaX-ray filmsInitial laboratory studiesPhysician awarenessUrinary phosphorusPatient's failureDietary phosphateCalcium levelsPhosphatase levelsOsteomalaciaFurther studiesHypercalciuriaHypophosphatemiaMalabsorptionPainAntacidsFailureSyndrome