Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone*
Williams BO, Insogna KL. Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone*. Journal Of Bone And Mineral Research 2009, 24: 171-178. PMID: 19072724, PMCID: PMC3276354, DOI: 10.1359/jbmr.081235.BooksConceptsEffects of WntWnt pathwayBone metabolismDuodenal enterochromaffin cellsBone anabolic agentAction of WntNoncanonical signaling pathwaysRegulation of sclerostinDownstream effector moleculesEndogenous Wnt inhibitorsBone cell metabolismImportant regulatory moleculesAnabolic actionEnterochromaffin cellsSmall molecule inhibitorsSerotonin synthesisDrug discoveryTrophic stimuliNew therapiesBone anabolismAnabolic agentsTherapeutic targetEndocrine fashionFinal pathwayCentral regulator