1989
Synthetic Parathyroid Hormone-Like Protein-(1–74): Biochemical and Physiological Characterization*
STEWART A, ELLIOT J, BURTIS W, WU T, INSOGNA K. Synthetic Parathyroid Hormone-Like Protein-(1–74): Biochemical and Physiological Characterization*. Endocrinology 1989, 124: 642-648. PMID: 2912692, DOI: 10.1210/endo-124-2-642.Peer-Reviewed Original ResearchConceptsAmino acid compositionDirect amino acid sequencingAmino acid sequencingAcid compositionPhysiological characterizationN-terminusParathyroid hormone-like proteinRenal cortical adenylate cyclaseFetal rat long bonesInternal sequencesTransduction mechanismsCortical adenylate cyclasePhysiological comparisonPTH-like proteinHormone-like proteinProteolytic fragmentsRat long bonesAdenylate cyclase assayBovine PTHProteinPTH receptorFull-length peptidePeptide hormonesSynthetic peptidesNovel class
1987
The relative potency of a human tumor‐derived PTH‐like adenylate cyclase‐stimulating preparation in three bioassays
Stewart A, Wu T, Burtis W, Weir E, Broadus A, Insogna K. The relative potency of a human tumor‐derived PTH‐like adenylate cyclase‐stimulating preparation in three bioassays. Journal Of Bone And Mineral Research 1987, 2: 37-43. PMID: 3455155, DOI: 10.1002/jbmr.5650020107.Peer-Reviewed Original ResearchConceptsFetal bone resorptionRat osteosarcomaPTH standardRelative potencyCyclase assaysPTH target tissuesAdenylate cyclase assayHumoral hypercalcemiaBone resorptionPTH receptorBPTH 1Target tissuesDistinct subpopulationsPotencyAssaysHypercalcemiaPrevious studiesMalignancyOsteosarcomaTumorsResorptionReceptors