Two Species of Adenylate Cyclase-Stimulating Activity in a Murine Squamous Carcinoma Model of Humoral Hypercalcemia of Malignancy*
BURTIS W, BROADUS A, INSOGNA K, WEIR E, STEWART A. Two Species of Adenylate Cyclase-Stimulating Activity in a Murine Squamous Carcinoma Model of Humoral Hypercalcemia of Malignancy*. Endocrinology 1986, 118: 1982-1988. PMID: 3009144, DOI: 10.1210/endo-118-5-1982.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesAnimalsBiological AssayCarcinoma, Squamous CellChromatography, High Pressure LiquidDisease Models, AnimalDogsHypercalcemiaKidney CortexMiceNeoplasm ProteinsOsteosarcomaParathyroid HormonePeptide FragmentsRatsReceptors, Cell SurfaceReceptors, Parathyroid HormoneSkin NeoplasmsConceptsAdenylate cyclase-stimulating activityCyclase-stimulating activityTumor extractsPTH antagonistHumoral hypercalcemiaRat osteosarcomaCarcinoma modelDose-response curve parallelRat Leydig cellsAdenylate cyclase activityAdenylate cyclase systemDose-response curvePostreceptor stepPTH (3-34) amideLeydig cellsReversed-phase HPLCCyclase systemCyclase activityPeak IICommon mediatorPTHCyclase assaysHypercalcemiaMalignancyPhase HPLCA Parathyroid Hormone-Like Protein from Cultured Human Keratinocytes
Merendino JJ, Insogna KL, Milstone LM, Broadus AE, Stewart AF. A Parathyroid Hormone-Like Protein from Cultured Human Keratinocytes. Science 1986, 231: 388-390. PMID: 2417317, DOI: 10.1126/science.2417317.Peer-Reviewed Original ResearchConceptsHumoral hypercalcemiaParathyroid hormoneHuman keratinocytesParathyroid hormone receptor agonistsParathyroid hormone-like proteinSquamous epithelial originExtracts of tumorsHormone receptor agonistsHormone-like proteinHormone-like factorsAdenylate cyclase activityRat osteosarcoma cellsAdenylate cyclase productionNative parathyroid hormoneCultured human keratinocytesNormal human keratinocytesReceptor agonistMalignant tumorsCyclic adenosine monophosphateHypercalcemiaEpithelial originKeratinocyte-conditioned mediumMalignancyCyclase activityCyclase production