2018
APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck
Sasaki T, Issaeva N, Yarbrough W, Anderson K. APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck. Current Cancer Research 2018, 275-292. DOI: 10.1007/978-3-319-78762-6_10.Peer-Reviewed Original ResearchDiverse physiological processesFamily of cytidineApolipoprotein B mRNA-editing enzyme catalytic polypeptideEnzyme catalytic polypeptideU conversionBioinformatics studiesEndogenous mutagensAPOBEC3 functionGenomic DNAPhysiological processesCatalytic polypeptideEditing mechanismBioinformatics dataAPOBEC activityHuman cancersTarget nucleotidesProduction of neoantigensAPOBEC3 proteinsDiverse cancersSquamous cell carcinomaHuman papillomavirus expressionTherapeutic avenuesProteinStructural evidenceDNA
2015
Biochemical and Functional Characterization of the Mutagenic Cytidine Deaminase, APOBEC3B
Sasaki T, Anderson K. Biochemical and Functional Characterization of the Mutagenic Cytidine Deaminase, APOBEC3B. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.573.48.Peer-Reviewed Original ResearchBiochemical experimentsMolecular mechanismsCytidine deaminaseFamily proteinsRNA editingBind DNANon-small cell lung cancerFunctional characterizationCellular cytidine deaminasesDiverse rolesEnzymatic capacityPhysiological processesPolypeptide 3APOBEC3BProteinProtein levelsSquamous cell lung carcinomaDeaminaseCatalytic polypeptide 3Cell lung carcinomaCell lung cancerCarcinogenesisTargeted treatment strategiesLung carcinomaTargeted therapy