2015
Chapter Twelve Cell Adhesion in Epidermal Development and Barrier Formation
Sumigray KD, Lechler T. Chapter Twelve Cell Adhesion in Epidermal Development and Barrier Formation. Current Topics In Developmental Biology 2015, 112: 383-414. PMID: 25733147, PMCID: PMC4737682, DOI: 10.1016/bs.ctdb.2014.11.027.Peer-Reviewed Original ResearchConceptsEpidermal developmentAdhesion proteinsCell-cell adhesionCell-cell junctionsCell biological studiesCell adhesion proteinsNoncanonical roleComposite proteinsAdhesive functionBarrier formationGrowth controlCell adhesionTissue physiologyProteinBiological studiesJunctional systemEpidermisTransductionAdhesionStructural integrityDifferentiationPhysiologyRoleFunctionJunction
2013
FRAP Analysis Reveals Stabilization of Adhesion Structures in the Epidermis Compared to Cultured Keratinocytes
Foote HP, Sumigray KD, Lechler T. FRAP Analysis Reveals Stabilization of Adhesion Structures in the Epidermis Compared to Cultured Keratinocytes. PLOS ONE 2013, 8: e71491. PMID: 23977053, PMCID: PMC3747223, DOI: 10.1371/journal.pone.0071491.Peer-Reviewed Original ResearchConceptsAdherens junctionsAdhesion structuresCell-cell adhesion structuresAdherens junction protein E-cadherinJunction protein E-cadherinCell-cell junctionsE-cadherinProtein E-cadherinDesmosomal protein desmoplakinZO-1Tight junctionsTissue morphogenesisTissue maintenanceFRAP analysisAdhesion functionProtein ZO-1Photobleaching experimentsProper developmentTight junction protein ZO-1Fluorescence recoveryCultured cellsDynamics of adhesionEpithelial tissuesCurrent understandingCell cultures
2012
Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation
Sumigray KD, Foote HP, Lechler T. Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. Journal Of Cell Biology 2012, 199: 513-525. PMID: 23091070, PMCID: PMC3483132, DOI: 10.1083/jcb.201206143.Peer-Reviewed Original ResearchConceptsReorganization of microtubulesAdherens junctionsNoncentrosomal microtubulesCortical microtubulesCell adhesionCell-cell junctionsMyosin II recruitmentType II myosinMost cell typesDisruption of microtubulesMicrotubule cytoskeletonCell cortexEpidermal cell adhesionMyosin IITight junction functionMyosin IIAEpidermal cellsPhysiological roleBarrier activityCell typesMicrotubulesJunction functionDifferentiating epidermisChemical barrierCell sheets