2015
The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine
Zhou K, Sumigray KD, Lechler T. The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine. Molecular Biology Of The Cell 2015, 26: 1995-2004. PMID: 25833710, PMCID: PMC4472011, DOI: 10.1091/mbc.e14-10-1481.Peer-Reviewed Original ResearchConceptsArp2/3 complexVesicle traffickingCell type-specific phenotypesCortical F-actinF-actin assemblyEssential roleMammalian small intestineF-actin filamentsCell polarityEndolysosomal systemEssential functionsF-actinCortical poolCell migrationCultured cellsIntestinal developmentTraffickingIntestinal epitheliumPhenotypeWide arrayComplexesComplex functionsTranscytosisLipid absorptionTranscytosis of IgG
2013
Rap1 and Canoe/afadin are essential for establishment of apical–basal polarity in the Drosophila embryo
Choi W, Harris NJ, Sumigray KD, Peifer M. Rap1 and Canoe/afadin are essential for establishment of apical–basal polarity in the Drosophila embryo. Molecular Biology Of The Cell 2013, 24: 945-963. PMID: 23363604, PMCID: PMC3608504, DOI: 10.1091/mbc.e12-10-0736.Peer-Reviewed Original ResearchMeSH KeywordsAdherens JunctionsAnimalsCell LineCell PolarityCell ShapeCytoskeletonDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianGreen Fluorescent ProteinsIntracellular Signaling Peptides and ProteinsMicroscopy, ConfocalModels, BiologicalMutationProtein Kinase CRap1 GTP-Binding ProteinsRNA InterferenceConceptsAtypical protein kinase CCanoe/AfadinPolarity establishmentPolarity cuesDrosophila embryosAdherens junctionsApical-basal cell polarityBazooka/Par3Apical-basal polarityAbsence of Rap1Columnar cell shapeSmall GTPase Rap1Protein kinase CCell polarityBazookaGTPase Rap1Protein networkRap1Cell shapeLinear pathwaySuperb modelKinase COrgan architectureAfadinCytoskeleton