2015
Chapter Twelve Cell Adhesion in Epidermal Development and Barrier Formation
Sumigray KD, Lechler T. Chapter Twelve Cell Adhesion in Epidermal Development and Barrier Formation. Current Topics In Developmental Biology 2015, 112: 383-414. PMID: 25733147, PMCID: PMC4737682, DOI: 10.1016/bs.ctdb.2014.11.027.Peer-Reviewed Original ResearchConceptsEpidermal developmentAdhesion proteinsCell-cell adhesionCell-cell junctionsCell biological studiesCell adhesion proteinsNoncanonical roleComposite proteinsAdhesive functionBarrier formationGrowth controlCell adhesionTissue physiologyProteinBiological studiesJunctional systemEpidermisTransductionAdhesionStructural integrityDifferentiationPhysiologyRoleFunctionJunction
2012
Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation
Sumigray KD, Foote HP, Lechler T. Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. Journal Of Cell Biology 2012, 199: 513-525. PMID: 23091070, PMCID: PMC3483132, DOI: 10.1083/jcb.201206143.Peer-Reviewed Original ResearchConceptsReorganization of microtubulesAdherens junctionsNoncentrosomal microtubulesCortical microtubulesCell adhesionCell-cell junctionsMyosin II recruitmentType II myosinMost cell typesDisruption of microtubulesMicrotubule cytoskeletonCell cortexEpidermal cell adhesionMyosin IITight junction functionMyosin IIAEpidermal cellsPhysiological roleBarrier activityCell typesMicrotubulesJunction functionDifferentiating epidermisChemical barrierCell sheetsDesmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium
Sumigray KD, Lechler T. Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium. Molecular Biology Of The Cell 2012, 23: 792-799. PMID: 22238362, PMCID: PMC3290639, DOI: 10.1091/mbc.e11-11-0923.Peer-Reviewed Original ResearchConceptsDesmosomal protein desmoplakinProper cell-cell adhesionCell adhesionSimple epitheliaCell adhesion structuresApical junctional regionCell-cell adhesionTissue-specific functionsFunction of desmosomesKeratin filament networkTight junctionsKeratin organizationAdherens junctionsTissue homeostasisIntestinal epitheliumAdhesion structuresFilament networkCanonical functionFilament localizationKeratin filamentsMicrovilli lengthMicrovillus structureStratified epitheliumDesmoplakinDesmosomes