2023
Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure
Harnett N, Fani N, Carter S, Sanchez L, Rowland G, Davie W, Guzman C, Lebois L, Ely T, van Rooij S, Seligowski A, Winters S, Grasser L, Musey P, Seamon M, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Harris E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Jovanovic T, Stevens J, Ressler K. Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure. Molecular Psychiatry 2023, 28: 2975-2984. PMID: 36725899, PMCID: PMC10615735, DOI: 10.1038/s41380-023-01971-x.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaFearGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance ImagingPrefrontal CortexStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderAmygdala connectivityAmygdala reactivityTrauma exposurePrefrontal cortexPTSD symptomsDorsal anterior cingulate cortexAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingGreater amygdala connectivityDorsolateral prefrontal cortexSymptoms 3Trauma outcomesSkin conductance levelCingulate cortexEthnic groupsEthnic disparitiesResonance imagingMultisite longitudinal studyStress disorderTwo weeksEthnic variabilityWhite individualsBlack participantsChildhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood
Ziobrowski H, Holt-Gosselin B, Petukhova M, King A, Lee S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Merchant R, Domeier R, Rathlev N, O'Neil B, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Ressler K, McLean S, Koenen K, Kessler R. Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood. Epidemiology And Psychiatric Sciences 2023, 32: e1. PMID: 36624694, PMCID: PMC9879881, DOI: 10.1017/s2045796022000798.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedDepressionDepressive Disorder, MajorHumansMiddle AgedMotor VehiclesStress Disorders, Post-TraumaticSurveys and QuestionnairesYoung AdultConceptsPosttraumatic stress disorderAdverse posttraumatic neuropsychiatric sequelaeChildhood adversityEmotional abuseStress disorderEmotional neglectChronic posttraumatic stress disorderSelf-report criteriaPeritraumatic symptomsTraumatic eventsPTSD ChecklistSexual abusePhysical neglectMajor depressive episodeMotor vehicle collisionsPhysical abuseDSM-5CA measuresBullyingAbuseStrongest predictorAdversityTrauma studiesDichotomous measureExposure frequencyUse of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
Beaudoin F, An X, Basu A, Ji Y, Liu M, Kessler R, Doughtery R, Zeng D, Bollen K, House S, Stevens J, Neylan T, Clifford G, Jovanovic T, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Murty V, McGrath M, Hudak L, Pascual J, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Neil B, Sergot P, Sanchez L, Bruce S, Baker J, Joormann J, Miller M, Pietrzak R, Barch D, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, Koenen K, Ressler K, McLean S. Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort. Translational Psychiatry 2023, 13: 4. PMID: 36609484, PMCID: PMC9823011, DOI: 10.1038/s41398-022-02289-y.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyAnxiety DisordersHumansRisk FactorsSmartphoneStress Disorders, Post-TraumaticSurvivors
2022
Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision
Jones C, An X, Ji Y, Liu M, Zeng D, House S, Beaudoin F, Stevens J, Neylan T, Clifford G, Jovanovic T, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Punches B, Lyons M, Kurz M, Swor R, McGrath M, Hudak L, Pascual J, Seamon M, Datner E, Harris E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O'Neil B, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, Koenen K, Ressler K, Kessler R, McLean S. Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision. Annals Of Emergency Medicine 2022, 81: 249-261. PMID: 36328855, PMCID: PMC11181458, DOI: 10.1016/j.annemergmed.2022.08.011.Peer-Reviewed Original ResearchMeSH KeywordsAccidents, TrafficAdultEmergency Service, HospitalHumansMotor VehiclesStress Disorders, Post-TraumaticConceptsMotor vehicle collisionsPosttraumatic stress symptomsValidation cohortSubstantial posttraumatic stress symptomsStress symptomsVehicle collisionsRisk-stratify individualsClinical decision support toolEmergency department patientsPersistent posttraumatic stress symptomsPreventive intervention trialNumber of EDsEase of administrationDerivation cohortPrimary outcomeDepartment patientsIntervention trialsBaseline healthHigh riskSymptomsCohortExternal validationPsychological recoveryDiscriminative abilityPosttraumatic stressStructural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis
Harnett NG, Finegold KE, Lebois LAM, van Rooij SJH, Ely TD, Murty VP, Jovanovic T, Bruce SE, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Chang AM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O’Neil B, Sergot P, Sanchez LD, Miller MW, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Nickerson LD, Ressler KJ, Stevens JS. Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis. Translational Psychiatry 2022, 12: 321. PMID: 35941117, PMCID: PMC9360028, DOI: 10.1038/s41398-022-02085-8.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaDreamsHumansMagnetic Resonance ImagingNeuroimagingStress Disorders, Post-TraumaticConceptsVentral visual streamPosttraumatic stress disorderVisual streamTrauma memoriesStructural covariance networksPTSD symptomsDevelopment of PTSDVisual componentsHigher PTSD symptom severityMultimodal magnetic resonance imaging (MRI) dataPTSD symptom severityFunctional covariance networkInferior temporal gyrusAdverse posttraumatic neuropsychiatric sequelaeCovariance networksPosttraumatic intrusionsTrauma exposureIntrusion symptomsStress disorderTemporal gyrusMagnetic resonance imaging dataNegative alterationsAffective disturbancesNightmare symptomsSymptom severityPrior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma
Harnett N, Dumornay N, Delity M, Sanchez L, Mohiuddin K, Musey P, Seamon M, McLean S, Kessler R, Koenen K, Beaudoin F, Lebois L, van Rooij S, Sampson N, Michopoulos V, Maples-Keller J, Haran J, Storrow A, Lewandowski C, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, McGrath M, Hudak L, Pascual J, House S, An X, Stevens J, Neylan T, Jovanovic T, Linnstaedt S, Germine L, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O'Neil B, Sergot P, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Smoller J, Luna B, Harte S, Elliott J, Ressler K. Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma. Psychological Medicine 2022, 53: 2553-2562. PMID: 35094717, PMCID: PMC9339026, DOI: 10.1017/s0033291721004475.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPrevious trauma exposureTrauma exposurePosttraumatic depressionPrior differencesChildhood emotional abusePrior trauma exposureSelf-report assessmentsWhite participantsPosttraumatic stressStress disorderAnxiety symptomsEmotional abuseLife stressorsPTSD ratesEarly aftermathPosttraumatic dysfunctionAnxietySymptom trajectoriesRecent traumaEthnic differencesAURORA studyParticipantsSymptom recoveryRecent research
2021
Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision
Ziobrowski HN, Kennedy CJ, Ustun B, House SL, Beaudoin FL, An X, Zeng D, Bollen KA, Petukhova M, Sampson NA, Puac-Polanco V, Lee S, Koenen KC, Ressler KJ, McLean SA, Kessler RC, Stevens J, Neylan T, Clifford G, Jovanovic T, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Lyons M, Murty V, McGrath M, Pascual J, Seamon M, Datner E, Chang A, Pearson C, Peak D, Jambaulikar G, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Harte S, Elliott J, van Rooij S. Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision. JAMA Psychiatry 2021, 78: 1228-1237. PMID: 34468741, PMCID: PMC8411364, DOI: 10.1001/jamapsychiatry.2021.2427.Peer-Reviewed Original ResearchMeSH KeywordsAccidents, TrafficAdolescentAdultAgedDepressive Disorder, MajorEmergency Service, HospitalFemaleHumansLongitudinal StudiesMachine LearningMaleMiddle AgedModels, TheoreticalPrognosisPsychological TraumaPsychometricsRisk AssessmentStress Disorders, Post-TraumaticWounds and InjuriesYoung AdultConceptsMajor depressive episodePosttraumatic stress disorderEmergency departmentUrban emergency departmentMotor vehicle collisionsSurvey 2 weeksDepressive episodeED assessmentMAIN OUTCOMEHigh riskPatientsPreventive interventionsED reportsPTSD ChecklistStress disorderSubstantial proportionLongitudinal studyVehicle collisionsDSM-5Prognostic reportsTraumatic eventsWeeksMonthsTraumatic experiencesReport