2024
Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study
Hyatt C, Reddi P, Sharpe B, Michopoulos V, van Rooij S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, McLean S, Kessler R, Ressler K, Koenen K, Maples-Keller J. Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study. Journal Of Research In Personality 2024, 112: 104524. DOI: 10.1016/j.jrp.2024.104524.Peer-Reviewed Original ResearchImpulsive personality traitsPTSD symptomsPersonality traitsOne-year post-traumaSevere PTSD symptomsPost-traumaFactor modelNegative urgencyLow agreeablenessLow conscientiousnessTrauma exposurePersonality assessmentPTSD riskProspective linksSymptom TotalPTSDLongitudinal associationsAURORA studyIncremental predictorNeuroticismTime pointsSymptomsTraitsAgreeablenessConscientiousnessIntensive longitudinal assessment following index trauma to predict development of PTSD using machine learning
Horwitz A, McCarthy K, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Joormann J, Harte S, Koenen K, McLean S, Sen S. Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning. Journal Of Anxiety Disorders 2024, 104: 102876. PMID: 38723405, PMCID: PMC11215748, DOI: 10.1016/j.janxdis.2024.102876.Peer-Reviewed Original ResearchTraumatic exposureIntensive longitudinal assessmentDevelopment of PTSDTrauma-related symptomsExposure to traumaFollow-up careTrauma exposureIndex traumaEmergency carePTSDAssess symptomsLongitudinal assessmentAssessment protocolCareParticipantsSymptomsFollow-upInterventionMachine learning analysisTraumaRiskIndividualsWeeksLearning analysisNervousness
2023
Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure
Wong S, Lebois L, Ely T, van Rooij S, Bruce S, Murty V, Jovanovic T, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Stevens J, Harnett N. Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure. Molecular Psychiatry 2023, 28: 5140-5149. PMID: 36932158, PMCID: PMC10505244, DOI: 10.1038/s41380-023-02012-3.Peer-Reviewed Original ResearchInternal capsuleDiffusion tensor imagingPosttraumatic dysfunctionWhite matter microstructureFractional anisotropyPTSD symptomsChildhood traumaRecent traumaChildhood maltreatmentTrauma exposureBilateral internal capsuleFuture PTSD symptomsAdulthood trauma exposureChildhood trauma exposureStress-related disordersWhite matter tractsPCL-5 scoresAssessment of PTSDSensory fibersEmergency departmentRisk factorsCorpus callosumNeural pathwaysCingulum bundleNeural circuitsPrior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study
Rowland G, Roeckner A, Ely T, Lebois L, van Rooij S, Bruce S, Jovanovic T, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Gentile N, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Stevens J, Harnett N. Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study. Biological Psychiatry Global Open Science 2023, 3: 705-715. PMID: 37881578, PMCID: PMC10593890, DOI: 10.1016/j.bpsgos.2023.02.004.Peer-Reviewed Original ResearchPrior sexual traumaPosttraumatic dysfunctionAcute trauma exposureLifetime trauma loadTrauma exposureSexual traumaTrauma loadNeural circuitryVisual cortex connectivitySexual trauma exposureTraumatic eventsMagnetic resonance imagingUnderlying neurobiological mechanismsPosttraumatic stress disorderPrevious sexual traumaRecent traumatic eventsEmergency departmentCortex connectivityAcute aftermathVisual processing regionsLeft amygdalaPosttraumatic depressionSubsequent traumatic eventsResonance imagingConnectivity differencesStructural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure
Harnett N, Fani N, Carter S, Sanchez L, Rowland G, Davie W, Guzman C, Lebois L, Ely T, van Rooij S, Seligowski A, Winters S, Grasser L, Musey P, Seamon M, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Harris E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Jovanovic T, Stevens J, Ressler K. Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure. Molecular Psychiatry 2023, 28: 2975-2984. PMID: 36725899, PMCID: PMC10615735, DOI: 10.1038/s41380-023-01971-x.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderAmygdala connectivityAmygdala reactivityTrauma exposurePrefrontal cortexPTSD symptomsDorsal anterior cingulate cortexAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingGreater amygdala connectivityDorsolateral prefrontal cortexSymptoms 3Trauma outcomesSkin conductance levelCingulate cortexEthnic groupsEthnic disparitiesResonance imagingMultisite longitudinal studyStress disorderTwo weeksEthnic variabilityWhite individualsBlack participants
2022
Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis
Harnett NG, Finegold KE, Lebois LAM, van Rooij SJH, Ely TD, Murty VP, Jovanovic T, Bruce SE, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Chang AM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O’Neil B, Sergot P, Sanchez LD, Miller MW, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Nickerson LD, Ressler KJ, Stevens JS. Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis. Translational Psychiatry 2022, 12: 321. PMID: 35941117, PMCID: PMC9360028, DOI: 10.1038/s41398-022-02085-8.Peer-Reviewed Original ResearchConceptsVentral visual streamPosttraumatic stress disorderVisual streamTrauma memoriesStructural covariance networksPTSD symptomsDevelopment of PTSDVisual componentsHigher PTSD symptom severityMultimodal magnetic resonance imaging (MRI) dataPTSD symptom severityFunctional covariance networkInferior temporal gyrusAdverse posttraumatic neuropsychiatric sequelaeCovariance networksPosttraumatic intrusionsTrauma exposureIntrusion symptomsStress disorderTemporal gyrusMagnetic resonance imaging dataNegative alterationsAffective disturbancesNightmare symptomsSymptom severityPrior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma
Harnett N, Dumornay N, Delity M, Sanchez L, Mohiuddin K, Musey P, Seamon M, McLean S, Kessler R, Koenen K, Beaudoin F, Lebois L, van Rooij S, Sampson N, Michopoulos V, Maples-Keller J, Haran J, Storrow A, Lewandowski C, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, McGrath M, Hudak L, Pascual J, House S, An X, Stevens J, Neylan T, Jovanovic T, Linnstaedt S, Germine L, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O'Neil B, Sergot P, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Smoller J, Luna B, Harte S, Elliott J, Ressler K. Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma. Psychological Medicine 2022, 53: 2553-2562. PMID: 35094717, PMCID: PMC9339026, DOI: 10.1017/s0033291721004475.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPrevious trauma exposureTrauma exposurePosttraumatic depressionPrior differencesChildhood emotional abusePrior trauma exposureSelf-report assessmentsWhite participantsPosttraumatic stressStress disorderAnxiety symptomsEmotional abuseLife stressorsPTSD ratesEarly aftermathPosttraumatic dysfunctionAnxietySymptom trajectoriesRecent traumaEthnic differencesAURORA studyParticipantsSymptom recoveryRecent research