2024
Neighborhood Resources Associated With Psychological Trajectories and Neural Reactivity to Reward After Trauma
Webb E, Stevens J, Ely T, Lebois L, van Rooij S, Bruce S, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Murty V, Hudak L, Pascual J, Seamon M, Datner E, Pearson C, Peak D, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Joormann J, Pizzagalli D, Harte S, Kessler R, Koenen K, Ressler K, McLean S, Harnett N. Neighborhood Resources Associated With Psychological Trajectories and Neural Reactivity to Reward After Trauma. JAMA Psychiatry 2024, 81 PMID: 39083325, PMCID: PMC11292566, DOI: 10.1001/jamapsychiatry.2024.2148.Peer-Reviewed Original ResearchPosttraumatic stress disorder trajectoriesPosttraumatic stress disorderNeural reactivityPTSD trajectoriesTrauma survivorsPosttraumatic stress disorder symptom severityDevelopment of posttraumatic stress disorderResidential greenspaceFunctional magnetic resonance imagingMonetary reward taskReactivity to rewardReward-related regionsCD-RISCCohort studyConnor-Davidson Resilience ScaleParticipant's home addressNeighborhood-level factorsCD-RISC scoreLongitudinal cohort studyReward reactivityReward taskSelf-reported characteristicsStress disorderIndividual-level factorsMultiple ecological levelsPost-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk
Garrison-Desany H, Meyers J, Linnstaedt S, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Jovanovic T, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Gentile N, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Joormann J, Harte S, McLean S, Koenen K, Denckla C. Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk. Frontiers In Psychiatry 2024, 15: 1249382. PMID: 38525258, PMCID: PMC10957776, DOI: 10.3389/fpsyt.2024.1249382.Peer-Reviewed Original ResearchPost-traumatic stress disorder symptomsPost-traumatic stress disorderCannabis usePhysical healthSubstance useSelf-rated physical healthPTSD symptomsAlcohol useAssociation of post-traumatic stress disorderFuture substancePoisson generalized estimating equationsProspective cohort of adultsSelf-reported PTSD symptomsPrevalent substance useAssociated with PTSD symptomsCohort of adultsPost-traumatic stressFuture substance useAssociated with tobaccoQuantity of tobaccoTobacco usePsychosocial characteristicsEffect modifiersEmergency departmentStress disorder
2023
Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals.
Hinojosa C, Liew A, An X, Stevens J, Basu A, van Rooij S, House S, Beaudoin F, Zeng D, Neylan T, Clifford G, Jovanovic T, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Fani N. Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals. Psychological Medicine 2023, 54: 338-349. PMID: 37309917, PMCID: PMC10716364, DOI: 10.1017/s0033291723001642.Peer-Reviewed Original ResearchPosttraumatic stress disorderDepression symptomsWeek 12Week 8Substance useMixed-model repeated-measures analysisStress disorderTrauma-exposed civiliansEmergency department visitsAssociation of alcoholParticipants' substance useGreater posttraumatic stress disorderRepeated-measures analysisTrauma-exposed individualsDepartment visitsWeeks posttraumaTherapeutic strategiesLatent class mixtureSymptoms 2Posttrauma psychopathologySymptomsCannabis useLower cannabisLower posttraumatic stress disorderLower PTSD symptomsStructural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure
Harnett N, Fani N, Carter S, Sanchez L, Rowland G, Davie W, Guzman C, Lebois L, Ely T, van Rooij S, Seligowski A, Winters S, Grasser L, Musey P, Seamon M, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Harris E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Jovanovic T, Stevens J, Ressler K. Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure. Molecular Psychiatry 2023, 28: 2975-2984. PMID: 36725899, PMCID: PMC10615735, DOI: 10.1038/s41380-023-01971-x.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderAmygdala connectivityAmygdala reactivityTrauma exposurePrefrontal cortexPTSD symptomsDorsal anterior cingulate cortexAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingGreater amygdala connectivityDorsolateral prefrontal cortexSymptoms 3Trauma outcomesSkin conductance levelCingulate cortexEthnic groupsEthnic disparitiesResonance imagingMultisite longitudinal studyStress disorderTwo weeksEthnic variabilityWhite individualsBlack participantsChildhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood
Ziobrowski H, Holt-Gosselin B, Petukhova M, King A, Lee S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Merchant R, Domeier R, Rathlev N, O'Neil B, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Ressler K, McLean S, Koenen K, Kessler R. Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood. Epidemiology And Psychiatric Sciences 2023, 32: e1. PMID: 36624694, PMCID: PMC9879881, DOI: 10.1017/s2045796022000798.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdverse posttraumatic neuropsychiatric sequelaeChildhood adversityEmotional abuseStress disorderEmotional neglectChronic posttraumatic stress disorderSelf-report criteriaPeritraumatic symptomsTraumatic eventsPTSD ChecklistSexual abusePhysical neglectMajor depressive episodeMotor vehicle collisionsPhysical abuseDSM-5CA measuresBullyingAbuseStrongest predictorAdversityTrauma studiesDichotomous measureExposure frequency
2022
Anxiety sensitivity as a transdiagnostic risk factor for trajectories of adverse posttraumatic neuropsychiatric sequelae in the AURORA study
Short NA, van Rooij SJH, Murty VP, Stevens JS, An X, Ji Y, McLean SA, House SL, Beaudoin FL, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, McGrath ME, Hudak LA, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Smoller JW, Harte SE, Elliott JM, Kessler RC, Koenen KC, Jovanovic T. Anxiety sensitivity as a transdiagnostic risk factor for trajectories of adverse posttraumatic neuropsychiatric sequelae in the AURORA study. Journal Of Psychiatric Research 2022, 156: 45-54. PMID: 36242943, PMCID: PMC10960961, DOI: 10.1016/j.jpsychires.2022.09.027.Peer-Reviewed Original ResearchConceptsAdverse posttraumatic neuropsychiatric sequelaeAnxiety sensitivityTransdiagnostic risk factorWeeks posttraumaPersistent trajectoryPersistent posttraumatic stressElevated anxiety sensitivityTrauma-related symptomsPosttraumatic stress disorderTrauma-related pathologySelf-report assessmentsNeuropsychiatric sequelaeAURORA studyPersonality-related factorsSleep disturbancesGrowth mixture modelingAnxious arousalPosttraumatic stressTrauma survivorsStress disorderBrief interventionPosttrauma periodSomatic symptomsMixture modelingPosttraumaStructural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis
Harnett NG, Finegold KE, Lebois LAM, van Rooij SJH, Ely TD, Murty VP, Jovanovic T, Bruce SE, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Chang AM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O’Neil B, Sergot P, Sanchez LD, Miller MW, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Nickerson LD, Ressler KJ, Stevens JS. Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis. Translational Psychiatry 2022, 12: 321. PMID: 35941117, PMCID: PMC9360028, DOI: 10.1038/s41398-022-02085-8.Peer-Reviewed Original ResearchConceptsVentral visual streamPosttraumatic stress disorderVisual streamTrauma memoriesStructural covariance networksPTSD symptomsDevelopment of PTSDVisual componentsHigher PTSD symptom severityMultimodal magnetic resonance imaging (MRI) dataPTSD symptom severityFunctional covariance networkInferior temporal gyrusAdverse posttraumatic neuropsychiatric sequelaeCovariance networksPosttraumatic intrusionsTrauma exposureIntrusion symptomsStress disorderTemporal gyrusMagnetic resonance imaging dataNegative alterationsAffective disturbancesNightmare symptomsSymptom severityPrior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma
Harnett N, Dumornay N, Delity M, Sanchez L, Mohiuddin K, Musey P, Seamon M, McLean S, Kessler R, Koenen K, Beaudoin F, Lebois L, van Rooij S, Sampson N, Michopoulos V, Maples-Keller J, Haran J, Storrow A, Lewandowski C, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, McGrath M, Hudak L, Pascual J, House S, An X, Stevens J, Neylan T, Jovanovic T, Linnstaedt S, Germine L, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O'Neil B, Sergot P, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Smoller J, Luna B, Harte S, Elliott J, Ressler K. Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma. Psychological Medicine 2022, 53: 2553-2562. PMID: 35094717, PMCID: PMC9339026, DOI: 10.1017/s0033291721004475.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPrevious trauma exposureTrauma exposurePosttraumatic depressionPrior differencesChildhood emotional abusePrior trauma exposureSelf-report assessmentsWhite participantsPosttraumatic stressStress disorderAnxiety symptomsEmotional abuseLife stressorsPTSD ratesEarly aftermathPosttraumatic dysfunctionAnxietySymptom trajectoriesRecent traumaEthnic differencesAURORA studyParticipantsSymptom recoveryRecent research
2021
Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision
Ziobrowski HN, Kennedy CJ, Ustun B, House SL, Beaudoin FL, An X, Zeng D, Bollen KA, Petukhova M, Sampson NA, Puac-Polanco V, Lee S, Koenen KC, Ressler KJ, McLean SA, Kessler RC, Stevens J, Neylan T, Clifford G, Jovanovic T, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Lyons M, Murty V, McGrath M, Pascual J, Seamon M, Datner E, Chang A, Pearson C, Peak D, Jambaulikar G, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Harte S, Elliott J, van Rooij S. Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision. JAMA Psychiatry 2021, 78: 1228-1237. PMID: 34468741, PMCID: PMC8411364, DOI: 10.1001/jamapsychiatry.2021.2427.Peer-Reviewed Original ResearchMeSH KeywordsAccidents, TrafficAdolescentAdultAgedDepressive Disorder, MajorEmergency Service, HospitalFemaleHumansLongitudinal StudiesMachine LearningMaleMiddle AgedModels, TheoreticalPrognosisPsychological TraumaPsychometricsRisk AssessmentStress Disorders, Post-TraumaticWounds and InjuriesYoung AdultConceptsMajor depressive episodePosttraumatic stress disorderEmergency departmentUrban emergency departmentMotor vehicle collisionsSurvey 2 weeksDepressive episodeED assessmentMAIN OUTCOMEHigh riskPatientsPreventive interventionsED reportsPTSD ChecklistStress disorderSubstantial proportionLongitudinal studyVehicle collisionsDSM-5Prognostic reportsTraumatic eventsWeeksMonthsTraumatic experiencesReport