2024
Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study
Holt-Gosselin B, Keding T, Rodrigues K, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study. Developmental Cognitive Neuroscience 2024, 68: 101400. PMID: 38870601, PMCID: PMC11225685, DOI: 10.1016/j.dcn.2024.101400.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentAdolescent depressive symptomsDepressive symptomsFamilial riskFunctional connectivityResting-state FC patternsCognitive developmentFamily history of depressionAdolescent-onset depressionLow familial riskHistory of depressionElevated familial riskMixed-effects regression analysisNucleus accumbensStriatal FCLR youthHR youthSensory/somatomotor networkFC patternsNeural circuitryNeural markersDepression riskDepressionPreadolescentsLongitudinal study
2023
Neural Circuit Markers of Familial Risk for Depression Among Healthy Youths in the Adolescent Brain Cognitive Development Study
Holt-Gosselin B, Keding T, Poulin R, Brieant A, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Neural Circuit Markers of Familial Risk for Depression Among Healthy Youths in the Adolescent Brain Cognitive Development Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 185-195. PMID: 37182734, PMCID: PMC10640659, DOI: 10.1016/j.bpsc.2023.05.001.Peer-Reviewed Original ResearchFamilial riskHR youthLR youthHealthy youthWhole-brain seedEarly-onset depressionResting-state FCYears of ageBrain-based markersFunctional connectivity patternsHigh familial riskCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyMaternal riskLow familial riskMaternal historyFamily historyStriatal connectivityMaternal depressionDepression riskNucleus accumbensPsychiatric problemsNeural circuitsEarly detectionSmall sample size