2024
Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk
Garrison-Desany H, Meyers J, Linnstaedt S, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Jovanovic T, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Gentile N, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Joormann J, Harte S, McLean S, Koenen K, Denckla C. Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk. Frontiers In Psychiatry 2024, 15: 1249382. PMID: 38525258, PMCID: PMC10957776, DOI: 10.3389/fpsyt.2024.1249382.Peer-Reviewed Original ResearchPost-traumatic stress disorder symptomsPost-traumatic stress disorderCannabis usePhysical healthSubstance useSelf-rated physical healthPTSD symptomsAlcohol useAssociation of post-traumatic stress disorderFuture substancePoisson generalized estimating equationsProspective cohort of adultsSelf-reported PTSD symptomsPrevalent substance useAssociated with PTSD symptomsCohort of adultsPost-traumatic stressFuture substance useAssociated with tobaccoQuantity of tobaccoTobacco usePsychosocial characteristicsEffect modifiersEmergency departmentStress disorder
2023
Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure
Wong S, Lebois L, Ely T, van Rooij S, Bruce S, Murty V, Jovanovic T, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Stevens J, Harnett N. Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure. Molecular Psychiatry 2023, 28: 5140-5149. PMID: 36932158, PMCID: PMC10505244, DOI: 10.1038/s41380-023-02012-3.Peer-Reviewed Original ResearchInternal capsuleDiffusion tensor imagingPosttraumatic dysfunctionWhite matter microstructureFractional anisotropyPTSD symptomsChildhood traumaRecent traumaChildhood maltreatmentTrauma exposureBilateral internal capsuleFuture PTSD symptomsAdulthood trauma exposureChildhood trauma exposureStress-related disordersWhite matter tractsPCL-5 scoresAssessment of PTSDSensory fibersEmergency departmentRisk factorsCorpus callosumNeural pathwaysCingulum bundleNeural circuitsUtility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure
Straus L, An X, Ji Y, McLean S, Neylan T, Cakmak A, Richards A, Clifford G, Liu M, Zeng D, House S, Beaudoin F, Stevens J, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Seamon M, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Harte S, Elliott J, Kessler R, Ressler K, Koenen K. Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure. JAMA Psychiatry 2023, 80: 220-229. PMID: 36630119, PMCID: PMC9857758, DOI: 10.1001/jamapsychiatry.2022.4533.Peer-Reviewed Original ResearchConceptsTraumatic stress exposureAdverse posttraumatic neuropsychiatric sequelaeEmergency departmentStress exposureNeuropsychiatric sequelaeGreater pain severityPain severityDerivation cohortNeuropsychiatric symptomsMean ageStudy criteriaSerial assessmentSleep disruptionMAIN OUTCOMEHigh incidenceUseful biomarkerBaseline assessmentPainSymptom severityDiverse cohortInformed consentPatientsSymptom domainsSleepDisadvantaged populationsPrior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study
Rowland G, Roeckner A, Ely T, Lebois L, van Rooij S, Bruce S, Jovanovic T, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Gentile N, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Stevens J, Harnett N. Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study. Biological Psychiatry Global Open Science 2023, 3: 705-715. PMID: 37881578, PMCID: PMC10593890, DOI: 10.1016/j.bpsgos.2023.02.004.Peer-Reviewed Original ResearchPrior sexual traumaPosttraumatic dysfunctionAcute trauma exposureLifetime trauma loadTrauma exposureSexual traumaTrauma loadNeural circuitryVisual cortex connectivitySexual trauma exposureTraumatic eventsMagnetic resonance imagingUnderlying neurobiological mechanismsPosttraumatic stress disorderPrevious sexual traumaRecent traumatic eventsEmergency departmentCortex connectivityAcute aftermathVisual processing regionsLeft amygdalaPosttraumatic depressionSubsequent traumatic eventsResonance imagingConnectivity differencesUse of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
Beaudoin F, An X, Basu A, Ji Y, Liu M, Kessler R, Doughtery R, Zeng D, Bollen K, House S, Stevens J, Neylan T, Clifford G, Jovanovic T, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Murty V, McGrath M, Hudak L, Pascual J, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Neil B, Sergot P, Sanchez L, Bruce S, Baker J, Joormann J, Miller M, Pietrzak R, Barch D, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, Koenen K, Ressler K, McLean S. Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort. Translational Psychiatry 2023, 13: 4. PMID: 36609484, PMCID: PMC9823011, DOI: 10.1038/s41398-022-02289-y.Peer-Reviewed Original Research
2021
Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision
Ziobrowski HN, Kennedy CJ, Ustun B, House SL, Beaudoin FL, An X, Zeng D, Bollen KA, Petukhova M, Sampson NA, Puac-Polanco V, Lee S, Koenen KC, Ressler KJ, McLean SA, Kessler RC, Stevens J, Neylan T, Clifford G, Jovanovic T, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Lyons M, Murty V, McGrath M, Pascual J, Seamon M, Datner E, Chang A, Pearson C, Peak D, Jambaulikar G, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Harte S, Elliott J, van Rooij S. Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision. JAMA Psychiatry 2021, 78: 1228-1237. PMID: 34468741, PMCID: PMC8411364, DOI: 10.1001/jamapsychiatry.2021.2427.Peer-Reviewed Original ResearchMeSH KeywordsAccidents, TrafficAdolescentAdultAgedDepressive Disorder, MajorEmergency Service, HospitalFemaleHumansLongitudinal StudiesMachine LearningMaleMiddle AgedModels, TheoreticalPrognosisPsychological TraumaPsychometricsRisk AssessmentStress Disorders, Post-TraumaticWounds and InjuriesYoung AdultConceptsMajor depressive episodePosttraumatic stress disorderEmergency departmentUrban emergency departmentMotor vehicle collisionsSurvey 2 weeksDepressive episodeED assessmentMAIN OUTCOMEHigh riskPatientsPreventive interventionsED reportsPTSD ChecklistStress disorderSubstantial proportionLongitudinal studyVehicle collisionsDSM-5Prognostic reportsTraumatic eventsWeeksMonthsTraumatic experiencesReport