Featured Publications
Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI
Sanganahalli BG, Baker KL, Thompson GJ, Herman P, Shepherd GM, Verhagen JV, Hyder F. Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI. NeuroImage 2020, 212: 116664. PMID: 32087375, PMCID: PMC9362851, DOI: 10.1016/j.neuroimage.2020.116664.Peer-Reviewed Original ResearchConceptsRat olfactory bulbOlfactory bulbWhole olfactory bulbOlfactory receptor neuronsFunctional MRINasal cavityRetronasal stimuliGlomerular sheetDorsal-medial regionsDelivery routeRetronasal stimulationSimilar response amplitudesGlomerular activityFMRI activation mapsSame odorReceptor neuronsDorsal regionNeural responsesOdor representationsLateral regionsSame odorantOrthonasalUnderlie differencesResponse amplitudeResponse patternsSpatiotemporal dynamics of odor responses in the lateral and dorsal olfactory bulb
Baker KL, Vasan G, Gumaste A, Pieribone VA, Verhagen JV. Spatiotemporal dynamics of odor responses in the lateral and dorsal olfactory bulb. PLOS Biology 2019, 17: e3000409. PMID: 31532763, PMCID: PMC6768483, DOI: 10.1371/journal.pbio.3000409.Peer-Reviewed Original ResearchPerception of Odors Linked to Precise Timing in the Olfactory System
Rebello MR, McTavish TS, Willhite DC, Short SM, Shepherd GM, Verhagen JV. Perception of Odors Linked to Precise Timing in the Olfactory System. PLOS Biology 2014, 12: e1002021. PMID: 25514030, PMCID: PMC4267717, DOI: 10.1371/journal.pbio.1002021.Peer-Reviewed Original Research
2023
Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCerebral CortexCerebrovascular CirculationHypercapniaMiceNeurovascular CouplingOlfactory BulbConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic wasteOdor encoding by signals in the olfactory bulb
Verhagen J, Baker K, Vasan G, Pieribone V, Rolls E. Odor encoding by signals in the olfactory bulb. Journal Of Neurophysiology 2023, 129: 431-444. PMID: 36598147, PMCID: PMC9925169, DOI: 10.1152/jn.00449.2022.Peer-Reviewed Original ResearchConceptsOlfactory bulbGlomerular responseMouse dorsalPresynaptic inputsLateral olfactory bulbSet of odorsGlomeruliOlfactory systemOdor identityOdor informationSniff onsetResponse latencyBroad tuningBulbStimulus identityLittle informationPopulationResponseEarly stagesTemporal encodingIndependent responses
2015
Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping
Sanganahalli BG, Rebello MR, Herman P, Papademetris X, Shepherd GM, Verhagen JV, Hyder F. Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping. NeuroImage 2015, 126: 208-218. PMID: 26631819, PMCID: PMC4733588, DOI: 10.1016/j.neuroimage.2015.11.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain MappingCalciumMagnetic Resonance ImagingOdorantsOlfactory BulbOptical ImagingRatsRats, Sprague-DawleySmellConceptsFunctional magnetic resonance imagingHigh-resolution functional magnetic resonance imagingPost-synaptic activityPre-synaptic inputOlfactory bulb glomeruliFunctional imaging signalsWide-field calcium imagingMagnetic resonance imagingHemodynamic eventsAnesthetized ratsGlomerular layerNeuronal circuitryGlomerular clustersGlomerular patternNeuropil regionsCalcium imagingDye imagingResonance imagingActivity patternsDeoxyhemoglobin contrastGlomerular activity patternsGlomerular sheetGlomerular networkGlomeruliDirect Behavioral and Neurophysiological Evidence for Retronasal Olfaction in Mice
Rebello MR, Kandukuru P, Verhagen JV. Direct Behavioral and Neurophysiological Evidence for Retronasal Olfaction in Mice. PLOS ONE 2015, 10: e0117218. PMID: 25675095, PMCID: PMC4326425, DOI: 10.1371/journal.pone.0117218.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalMaleMiceModels, AnimalOdorantsOlfactory BulbOlfactory Receptor NeuronsOptical ImagingSmellTasteConceptsOlfactory bulbMouse's abilityAdditional animal modelsHead-fixed miceConcentration-dependent mannerAnesthetized ratsAwake miceRetronasal odorantsRetronasal odorCalcium responseAnimal modelsTransgenic miceMiceRatsRetronasal olfactionGo behavioral taskRetronasal smellLick spoutFood flavor perceptionNeurophysiological evidenceBehavioral tasksHuman flavor perceptionFood selectionOlfactionBulbectomy