2010
β4-Subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells
Bai JP, Surguchev A, Navaratnam D. β4-Subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells. American Journal Of Physiology - Cell Physiology 2010, 300: c435-c446. PMID: 21178105, PMCID: PMC3063969, DOI: 10.1152/ajpcell.00449.2010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium SignalingCell MembraneChickensCochleaDown-RegulationHair Cells, AuditoryIon Channel GatingLarge-Conductance Calcium-Activated Potassium Channel beta SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMechanotransduction, CellularMembrane PotentialsOocytesXenopus laevisConceptsLow-frequency hair cellsHair cellsLarge-conductance potassium channelsBK channelsSurface expressionBK channel functionNonmammalian vertebratesAccessory subunitsΑ-subunitMolecular underpinningsΒ-subunitChannel functionSubunitsΒ4 subunitPhysiological Ca2Critical rolePotassium channelsCellsBK currentsAdditional mechanismExpressionVertebratesDramatic increaseChicksIntracellular
2009
Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent
Bai JP, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J, Navaratnam D. Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent. Biophysical Journal 2009, 96: 3179-3186. PMID: 19383462, PMCID: PMC2718310, DOI: 10.1016/j.bpj.2008.12.3948.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnalysis of VarianceAnimalsAnion Transport ProteinsAntiportersCarbon RadioisotopesChloridesCHO CellsCricetinaeCricetulusElectric CapacitanceFormatesGerbillinaeIon TransportMiceMutation, MissenseOxalatesPatch-Clamp TechniquesSalicylatesSulfate TransportersConceptsClosest phylogenetic relativesTransmembrane regionSLC26 anion transporter familyMammalian outer hair cellsMembrane protein prestinPrestin's motor functionAnion transportPhylogenetic relativesAnion transporter familyTransporter familyProtein prestinChloride-binding siteGating charge movementPrestinCharge movementHair cellsOuter hair cellsResiduesMechanistic conceptsVoltage sensingTransport capabilityCellsVoltage sensorPrevious observationsUptake studies