2009
microRNA Expression during Trophectoderm Specification
Viswanathan SR, Mermel CH, Lu J, Lu CW, Golub TR, Daley GQ. microRNA Expression during Trophectoderm Specification. PLOS ONE 2009, 4: e6143. PMID: 19582159, PMCID: PMC2702083, DOI: 10.1371/journal.pone.0006143.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlastocystCell DifferentiationCell LineageEctodermMiceMicroRNAsPluripotent Stem CellsConceptsEmbryonic stem cellsTrophectoderm specificationPreimplantation developmentMurine embryosFirst cell fate decisionCell fate decisionsTight developmental regulationStem cellsInner cell massCandidate miRNAsNumber of miRNAsStages of embryogenesisRole of microRNAsMiRNA expression changesMammalian developmentTranscription factorsDevelopmental regulationEctopic expressionTarget genesExpression changesTrophectodermal cellsTrophectodermMiRNA expressionFunctional roleMiRNAs
2008
The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells
Chou YF, Chen HH, Eijpe M, Yabuuchi A, Chenoweth JG, Tesar P, Lu J, McKay RD, Geijsen N. The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells. Cell 2008, 135: 449-461. PMID: 18984157, PMCID: PMC2767270, DOI: 10.1016/j.cell.2008.08.035.Peer-Reviewed Original ResearchConceptsStem cell linesGrowth factor environmentPluripotent stateTissue of originCell linesEmbryonic stem cell linesPluripotent ground stateBlastocyst embryosStem cell identityCell-cell interactionsGrowth factor conditionsStem cell typesFactor environmentPostimplantation epiblastCell identityES cellsDevelopmental stagesCell typesStem cellsFunctional differencesCritical roleEmbryosGrowth factorGrowth factor milieuEpiSCs