Jun He, PhD, MPH
he/him/his
Postdoctoral FellowAbout
Research
Publications
2024
47. GENE DISCOVERY AND BIOLOGICAL INSIGHTS INTO ANXIETY DISORDERS FROM A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF > 1.2 MILLION PARTICIPANTS
Friligkou E, Løkhammer S, Mendoza B, Shen J, He J, Deiana G, Zanoaga M, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee D, Pathak G, Polimanti R. 47. GENE DISCOVERY AND BIOLOGICAL INSIGHTS INTO ANXIETY DISORDERS FROM A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF > 1.2 MILLION PARTICIPANTS. European Neuropsychopharmacology 2024, 87: 74-75. DOI: 10.1016/j.euroneuro.2024.08.161.Peer-Reviewed Original ResearchMillion Veteran ProgramPolygenic riskLatent causal variable methodMulti-tissue transcriptome-wide association studyUK Biobank (UKBGenetic correlationsTranscriptome-wide association studyAnxiety disordersGenomic structural equation modelingLD score regressionLocal genetic correlationGWAS meta-analysisProteome-wide analysisGenetics of anxietyAssociated with anxietyMulti-omics informationS-MultiXcanVeteran ProgramLD scoresAncestry-specificTranscriptome-wideAncestral populationsCross-ancestryGene discoveryAssociation studiesGene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study
Friligkou E, Løkhammer S, Cabrera-Mendoza B, Shen J, He J, Deiana G, Zanoaga M, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee D, Pathak G, Polimanti R. Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study. Nature Genetics 2024, 56: 2036-2045. PMID: 39294497, DOI: 10.1038/s41588-024-01908-2.Peer-Reviewed Original ResearchGenome-wide association studiesAnxiety disordersAssociation studiesMulti-ancestry genome-wide association studyPathogenesis of anxiety disordersHeritability of anxietyLocal genetic correlationProteome-wide analysisIndividuals of European descentAssociated with anxietyMulti-omics informationWidespread pleiotropyTranscriptome-widePolygenic risk scoresBipolar disorderAncestry-specificGene discoveryContinental groupsLimbic systemEast Asian groupsBiological insightsAnxietyEntorhinal cortexPhysical health domainBrain-specificDistinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records
Løkhammer S, Koller D, Wendt F, Choi K, He J, Friligkou E, Overstreet C, Gelernter J, Hellard S, Polimanti R. Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records. Psychiatry Research 2024, 337: 115950. PMID: 38744179, PMCID: PMC11156529, DOI: 10.1016/j.psychres.2024.115950.Peer-Reviewed Original ResearchElectronic health recordsPosttraumatic stress disorderHealth recordsPTSD vulnerabilityUK Biobank (UKBPhenome-wide association studyRisk scorePhenotype risk scoreUs Research ProgramPolygenic risk scoresStress disorderAoU participantsUKB participantsPresence of posttraumatic stress disorderTrauma burdenGenetic riskPosttraumatic stress disorder symptomsAssociation studiesPheWASClinical comorbiditiesComorbid associationsEye conditionsAOUInverse relationshipMultiple phenotypesSex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation
He J, Cabrera-Mendoza B, De Angelis F, Pathak G, Koller D, Curhan S, Curhan G, Mecca A, van Dyck C, Polimanti R. Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. Brain 2024, 147: 3395-3408. PMID: 38454550, PMCID: PMC11449129, DOI: 10.1093/brain/awae077.Peer-Reviewed Original ResearchImaging-derived phenotypesHearing difficultiesBrain imaging-derived phenotypesSex-combined analysisLatent causal variable analysesMendelian randomization approachGeneralized linear regression analysisLocal genetic correlation analysisMultivariate generalized linear regression analysisGenome-wide association studiesLatent causal variableGenetic correlation analysisGenetic correlationsLocal genetic correlationMendelian randomizationPeripheral auditory systemOlder adultsGWAS dataLinear regression analysisHealth burdenGenomic regionsAssociation studiesPleiotropic regionsSex differencesTranscriptome regulation
2023
Brainwide Mendelian Randomization Study of Anxiety Disorders and Symptoms
Zanoaga M, Friligkou E, He J, Pathak G, Koller D, Cabrera-Mendoza B, Stein M, Polimanti R. Brainwide Mendelian Randomization Study of Anxiety Disorders and Symptoms. Biological Psychiatry 2023, 95: 810-817. PMID: 37967698, PMCID: PMC10978301, DOI: 10.1016/j.biopsych.2023.11.006.Peer-Reviewed Original ResearchImaging-derived phenotypesMiddle cingulate gyrusBrain imaging-derived phenotypesCingulate gyrusBrain structuresMultivariable Mendelian randomization analysesRight anterior superior temporal gyrusGray matter volumeMendelian randomizationAnterior superior temporal gyrusUK BiobankMendelian randomization studyFalse discovery rate correctionSuperior temporal gyrusMultivariable Mendelian randomizationMendelian randomization analysisMillion Veteran ProgramLarge cohortMatter volumeRandomization studySymptom-level analysesTemporal gyrusAnxiety disordersRandomization analysisGyrusStressful Life Events, Unhealthy Eating Behaviors and Obesity among Chinese Government Employees: A Follow-Up Study
Qiu D, He J, Li Y, Ouyang F, Xiao S. Stressful Life Events, Unhealthy Eating Behaviors and Obesity among Chinese Government Employees: A Follow-Up Study. Nutrients 2023, 15: 2637. PMID: 37299600, PMCID: PMC10255864, DOI: 10.3390/nu15112637.Peer-Reviewed Original ResearchConceptsHigher risk of obesityUnhealthy eating behaviorsRisk of obesityFollow-upEating behaviorsStressful life eventsAssociated with obesityIrregular meal timesLife eventsFollow-up studyFollowed-upObesityMeal timesBaselineLife Events ScaleChinese government employeesGovernment employeesChinese workersEvent ScaleReportsTrends in mortality and causes of death among Chinese adolescents aged 10–19 years from 1990 to 2019
Zhu J, Li Y, Zhang C, He J, Niu L. Trends in mortality and causes of death among Chinese adolescents aged 10–19 years from 1990 to 2019. Frontiers In Public Health 2023, 11: 1075858. PMID: 36825144, PMCID: PMC9941149, DOI: 10.3389/fpubh.2023.1075858.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesNon-communicable disease mortality ratesAdolescent HealthRates of non-communicable diseasesGlobal Burden of Disease StudyMortality rateBurden of Disease StudyPromote adolescent healthChinese adolescentsAdolescent mortality ratesAdolescent mortalityGlobal burdenRoad injuriesSelf-harmHealthy ChinaAge disparitiesHigher mortalityDisease StudyMedical practiceCongenital birth defectsSocioeconomic conditionsHealthRate of communicationDisease patternsNutritional diseasesAssociation of Healthy Lifestyles with Non-Alcoholic Fatty Liver Disease: A Prospective Cohort Study in Chinese Government Employees
Ling Z, Zhang C, He J, Ouyang F, Qiu D, Li L, Li Y, Li X, Duan Y, Luo D, Xiao S, Shen M. Association of Healthy Lifestyles with Non-Alcoholic Fatty Liver Disease: A Prospective Cohort Study in Chinese Government Employees. Nutrients 2023, 15: 604. PMID: 36771311, PMCID: PMC9921275, DOI: 10.3390/nu15030604.Peer-Reviewed Original ResearchConceptsHealthy lifestyle factorsLifestyle factorsBody mass indexLow-risk factorsChinese government employeesAssociations of healthy lifestyleCohort studyHealthy lifestyle patternNon-sedentary behaviorIncidence of non-alcoholic fatty liver diseaseNormal body mass indexRisk of non-alcoholic fatty liver diseaseOR of NAFLDNon-alcoholic fatty liver diseaseProspective cohort studyLogistic regression modelsPhysical activityAssociated with non-alcoholic fatty liver diseaseHealthy lifestyleLifestyle patternsHealthy dietMass indexGovernment employeesFatty liver diseaseRegression models
2022
Increased Mortality Trends in Patients With Chronic Non-communicable Diseases and Comorbid Hypertension in the United States, 2000–2019
Ouyang F, Cheng X, Zhou W, He J, Xiao S. Increased Mortality Trends in Patients With Chronic Non-communicable Diseases and Comorbid Hypertension in the United States, 2000–2019. Frontiers In Public Health 2022, 10: 753861. PMID: 35899158, PMCID: PMC9309719, DOI: 10.3389/fpubh.2022.753861.Peer-Reviewed Original ResearchConceptsAverage annual percent changeNon-communicable diseasesAnnual percent changeChronic respiratory diseasesMortality trendsPercent changeCardiovascular diseaseMortality rateCVD mortality ratesIncreasing mortality trendCenters for Disease Control and PreventionConfidence intervalsComorbid hypertensionDisease Control and PreventionDiabetes mellitusControl and PreventionNCD mortalityCVD mortalityUnited StatesMortality dataMinimize disparitiesDemographic subgroupsHypertension-related cardiovascular diseasesIncreased mortality rateRural SouthStressful Life Events and Chronic Fatigue Among Chinese Government Employees: A Population-Based Cohort Study
Qiu D, He J, Li Y, Li R, Ouyang F, Li L, Luo D, Xiao S. Stressful Life Events and Chronic Fatigue Among Chinese Government Employees: A Population-Based Cohort Study. Frontiers In Public Health 2022, 10: 890604. PMID: 35875038, PMCID: PMC9300904, DOI: 10.3389/fpubh.2022.890604.Peer-Reviewed Original ResearchConceptsAssociated with self-reported fatigueSelf-reported fatigueStressful life eventsChinese government employeesNegative stressful life eventsLife Events ScaleLife eventsHealth behavior related factorsPopulation-based cohort studyChronic fatigueAssociated with fatigueBehavior related factorsCumulative life eventsBinary logistic regression analysisParticipants' healthGovernment employeesFollow-upLogistic regression analysisSociodemographic factorsAssociated with lower incidenceProspective associationsEffective interventionsNegative life eventsCohort studyPositive stressful life events