Featured Publications
Consensuses, controversies, and future directions in treatment deintensification for human papillomavirus‐associated oropharyngeal cancer
Kang J, Yu Y, Chen L, Zakeri K, Gelblum D, McBride S, Riaz N, Tsai C, Kriplani A, Hung T, Fetten J, Dunn L, Ho A, Boyle J, Ganly I, Singh B, Sherman E, Pfister D, Wong R, Lee N. Consensuses, controversies, and future directions in treatment deintensification for human papillomavirus‐associated oropharyngeal cancer. CA A Cancer Journal For Clinicians 2022, 73: 164-197. PMID: 36305841, PMCID: PMC9992119, DOI: 10.3322/caac.21758.Peer-Reviewed Original ResearchMeSH KeywordsConsensusHuman Papillomavirus VirusesHumansOropharyngeal NeoplasmsPapillomavirus InfectionsProspective StudiesConceptsTransoral robotic surgeryOropharyngeal cancerDeintensification strategiesHuman papillomavirus-associated oropharyngeal cancerSubstantial long-term morbidityHPV-positive oropharyngeal cancerNational database studyHuman papillomavirus infectionLong-term morbidityThird of patientsDe-escalation trialsLevel I evidenceStandard of careCurrent treatment standardsOptimal patient outcomesDeintensification trialsTreatment deintensificationAdjuvant therapyHPV statusPapillomavirus infectionFavorable prognosisI evidenceMedical oncologyTreatment indicationsCommon cancer
2021
Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy
Li X, Kitpanit S, Lee A, Mah D, Sine K, Sherman EJ, Dunn LA, Michel LS, Fetten J, Zakeri K, Yu Y, Chen L, Kang JJ, Gelblum DY, McBride SM, Tsai CJ, Riaz N, Lee NY. Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy. JAMA Network Open 2021, 4: e2113205. PMID: 34143193, PMCID: PMC8214161, DOI: 10.1001/jamanetworkopen.2021.13205.Peer-Reviewed Original ResearchConceptsLocoregional failure-free survivalNonmetastatic nasopharyngeal carcinomaProgression-free survivalIntensity-modulated radiation therapyIntensity-modulated proton therapyCurative-intent radiotherapyIMPT groupIMRT groupAdverse eventsOncologic outcomesOverall survivalSurvival outcomesNasopharyngeal carcinomaMAIN OUTCOMERadiation therapyToxicity profileHigher acute adverse eventsSimilar progression-free survivalTertiary academic cancer centerTreatment-related adverse eventsPropensity score-matched analysisTreatment-related toxic effectsMultivariable logistic regression analysisPoor progression-free survivalChronic grade 3