2024
Outcomes of Reduced Elective Nodal Radiation Dose for Laryngeal, Hypopharyngeal and p16 Negative Oropharyngeal Cancers
Zakeri K, Shang T, Yu Y, Chen L, Shamseddine A, Kang J, Tsai C, Sherman E, Wong R, McBride S, Gelblum D, Riaz N, Lee N. Outcomes of Reduced Elective Nodal Radiation Dose for Laryngeal, Hypopharyngeal and p16 Negative Oropharyngeal Cancers. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e807. DOI: 10.1016/j.ijrobp.2024.07.1772.Peer-Reviewed Original ResearchP16-negative oropharyngeal squamous cell carcinomaNegative oropharyngeal squamous cell carcinomasOropharyngeal squamous cell carcinomaDistant recurrenceSquamous cell carcinomaNodal recurrenceRadiotherapy doseLocoregional recurrenceP16 statusCell carcinomaHypopharynx cancerP16-negative oropharyngeal cancerHead and neck cancer patientsRadiation doseElective nodal volumesP16-negative diseaseNode-positive diseaseDecrease treatment toxicityNeck cancer patientsPrimary outcome measureConcurrent cetuximabConcurrent chemotherapyLocoregional controlMedian followNodal disease
2022
Outcomes for Organ Preservation with Chemoradiation Therapy for T4 Larynx and Hypopharynx Cancer
Eita A, Mohamed N, Rybkin A, Kang J, Fiasconaro M, Zhigang Z, Zakeri K, Yu Y, Sadaka E, Sherman E, Dunn L, Cracchiolo J, Wong R, Cohen M, Lee N. Outcomes for Organ Preservation with Chemoradiation Therapy for T4 Larynx and Hypopharynx Cancer. The Laryngoscope 2022, 133: 1138-1145. PMID: 35801573, PMCID: PMC10547133, DOI: 10.1002/lary.30279.Peer-Reviewed Original ResearchConceptsUnivariate analysisLocoregional failureT4 laryngealNonoperative managementHypopharyngeal cancerRadiation therapyPercutaneous endoscopic gastrostomy tubeHypopharynx cancer patientsYear OS ratesDisease-free survivalNon-surgical managementHypopharynx groupsInoperable diseaseLast followUnresectable diseaseChemoradiation therapyNodal statusGastrostomy tubeHypopharynx cancerOS ratesStage T4Cancer patientsFunctional outcomeTracheostomy tubeOrgan preservation
2021
Long-term Therapeutic and Functional Outcomes With Organ Preservation for T4 Larynx and Hypopharynx Cancers
Rybkin A, Eita A, Kang J, Fiasconaro M, Zhang Z, Zakeri K, Yu Y, Chen L, Gelblum D, Tsai C, Riaz N, McBride S, Sherman E, Dunn L, Ho A, Cohen M, Cracchiolo J, Pfister D, Wong R, Lee N. Long-term Therapeutic and Functional Outcomes With Organ Preservation for T4 Larynx and Hypopharynx Cancers. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: e365-e366. DOI: 10.1016/j.ijrobp.2021.07.1084.Peer-Reviewed Original ResearchPercutaneous endoscopic gastrostomyDisease-free survivalHypopharynx cancerLocoregional failureOverall survivalUnivariate analysisChemoradiation therapyRadiation therapySurgical candidatesDistant metastasisStage T4Functional outcomeMedian disease-free intervalAdequate supportive careOrgan preservation trialsYear OS ratesDefinitive radiation therapyDisease-free intervalKaplan-Meier methodLarynx groupSupportive careEndoscopic gastrostomyMethods PatientsNodal statusNonoperative management