2021
Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease
Srivastava SP, Goodwin JE, Tripathi P, Kanasaki K, Koya D. Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease. International Journal Of Molecular Sciences 2021, 22: 6027. PMID: 34199672, PMCID: PMC8199750, DOI: 10.3390/ijms22116027.Peer-Reviewed Original ResearchConceptsDiabetic kidney diseaseKidney diseaseLarge-scale RNA sequencingGenome-wide profiling dataLong non-coding RNAsNon-coding RNAsDisease phenotypeTherapeutic targetNoncoding RNAsRNA sequencingPathogenesis of diabetesPotential therapeutic targetCrosstalk mechanismsRegulatory microRNAsCrosstalk interactionsLncRNAsMechanism of actionProfiling dataMicroRNAsAberrant expressionDiverse targetsDisease processDiabetesRNADisease
2020
Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs
Srivastava SP, Goodwin JE, Kanasaki K, Koya D. Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs. Genes 2020, 11: 211. PMID: 32085655, PMCID: PMC7074526, DOI: 10.3390/genes11020211.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAnimalsCell LineDiabetes Mellitus, ExperimentalDiabetic NephropathiesDipeptidyl Peptidase 4Disease Models, AnimalDrug SynergismGene Expression RegulationHumansMiceMicroRNAsOligopeptidesSignal TransductionTransforming Growth Factor betaConceptsAngiotensin II receptor blockersRenal fibrosisDPP-4End-stage renal diseaseSubstrates of ACEDiabetic kidney diseaseEffect of ACEIII receptor blockersDPP-4 levelsTGFβ signalingAngiotensin converting enzymeChronic nephropathyReceptor blockersRenal diseaseKidney diseaseACEIEnzyme inhibitorsConventional drugsDownregulated expressionEndothelial cellsFibrosisInhibitory effectDrug 1MiR-29AcSDKP
2019
Characterization of Circular RNA and microRNA Profiles in Septic Myocardial Depression: a Lipopolysaccharide-Induced Rat Septic Shock Model
Zhang TN, Yang N, Goodwin JE, Mahrer K, Li D, Xia J, Wen R, Zhou H, Zhang T, Song WL, Liu CF. Characterization of Circular RNA and microRNA Profiles in Septic Myocardial Depression: a Lipopolysaccharide-Induced Rat Septic Shock Model. Inflammation 2019, 42: 1990-2002. PMID: 31332662, DOI: 10.1007/s10753-019-01060-8.Peer-Reviewed Original ResearchConceptsCircular RNAsDifferential expressionGene Ontology term enrichmentFeatures of circRNAsMiRNA-mRNA networkMicroRNA profilesBasic molecular mechanismsNovel miRNAsCellular functionsRegulatory networksTerm enrichmentRNA sequencingBioinformatics analysisComprehensive circRNARegulator networkRegulatory relationshipsMolecular mechanismsCircRNAsMetabolic processesMiRNAsHeart tissueBiological mechanismsMiRNARNAPathological processes