Endothelial glucocorticoid receptor is required for protection against sepsis
Goodwin JE, Feng Y, Velazquez H, Sessa WC. Endothelial glucocorticoid receptor is required for protection against sepsis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 110: 306-311. PMID: 23248291, PMCID: PMC3538225, DOI: 10.1073/pnas.1210200110.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCorticosteroneEndotheliumGene DeletionHemodynamicsHuman Umbilical Vein Endothelial CellsHumansIn Situ Nick-End LabelingInterleukin-6LipopolysaccharidesMaleMiceMice, KnockoutNF-kappa BNitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIReceptors, GlucocorticoidSepsisTumor Necrosis Factor-alphaConceptsEndothelial nitric oxide synthaseEndothelial glucocorticoid receptorHuman umbilical vein cellsGlucocorticoid receptorInterleukin-6Inducible nitric oxide synthase (iNOS) expressionExpression of eNOSNitric oxide synthase expressionHigher nitric oxide levelsOxide synthase expressionNitric oxide levelsNF-κB levelsSpecific iNOS inhibitorNitric oxide synthaseNitric oxide synthesisNF-κB activationRate of apoptosisHemodynamic collapseHemodynamic instabilityTissue-specific deletionUmbilical vein cellsInflammatory cytokinesINOS inhibitorTumor necrosisOxide synthase