The Glucocorticoid Receptor in Cardiovascular Health and Disease
Liu B, Zhang TN, Knight JK, Goodwin JE. The Glucocorticoid Receptor in Cardiovascular Health and Disease. Cells 2019, 8: 1227. PMID: 31601045, PMCID: PMC6829609, DOI: 10.3390/cells8101227.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorGlucocorticoid signalingCardiovascular systemNon-genomic pathwaysClinical outcomesExogenous glucocorticoidsGlucocorticoid treatmentCardiovascular healthCardiovascular diseaseNuclear receptor familyTherapeutic strategiesAnimal modelsSteroid hormone cortisolHormone cortisolPathological conditionsReceptorsDiseaseReceptor familySignalingDistinct gene networksHuman diseasesDirect effectCritical roleInflammationPrognosisRole of the glucocorticoid receptor in glomerular disease
Goodwin JE. Role of the glucocorticoid receptor in glomerular disease. American Journal Of Physiology. Renal Physiology 2019, 317: f133-f136. PMID: 31166704, PMCID: PMC6692724, DOI: 10.1152/ajprenal.00217.2019.Peer-Reviewed Original ResearchConceptsGlomerular diseasePotent anti-inflammatory agentSteroid delivery systemsAnti-inflammatory agentsSystemic steroidsBeneficial direct effectsUnfavorable riskSystemic administrationTherapeutic benefitGlucocorticoid receptorRisk assessment algorithmClinicians' effortsBenefit ratioVivo studiesGlucocorticoidsDiseasePersonalized medicineDirect effectDelivery systemGlomeruliSteroidsAdministrationPodocytesReceptors