2024
Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease
Zhang W, Gonzalez L, Li X, Bai H, Li Z, Taniguchi R, Langford J, Ohashi Y, Thaxton C, Aoyagi Y, Yatsula B, Martin K, Goodwin J, Tellides G, Long X, Shu C, Dardik A. Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 2509-2526. PMID: 39297205, PMCID: PMC11593991, DOI: 10.1161/atvbaha.124.320933.Peer-Reviewed Original ResearchChronic kidney diseaseTGF-b signalingArteriovenous fistula patencyArteriovenous fistulaKidney diseaseAVF patencyEndothelial cellsAssociated with endothelial injuryArteriovenous fistula diameterImprove AVF patencyIncreased outward remodelingReduced patencyInduced endothelial-to-mesenchymal transitionAortocaval fistula modelSmooth muscle cell proliferationArteriovenous fistula failureAttenuated EndMTEnd-stage kidney diseaseHuman arteriovenous fistulaeSmooth muscle cellsMuscle cell proliferationEndothelial-to-mesenchymal transitionMouse endothelial cellsInhibition of EndMTEndothelial-mesenchymal transition
2023
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2023, 195-215. DOI: 10.1007/978-3-031-06231-5_41.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsEndothelium contributesKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseCommon conditionRare diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesDiseaseRemodeling
2022
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2022, 1-21. DOI: 10.1007/978-3-319-31420-4_41-2.BooksEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsEndothelium contributesKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseCommon conditionRare diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesDiseaseRemodeling
2018
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2018, 205-219. DOI: 10.1007/978-3-319-31107-4_41.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesRemodelingHemodynamic forcesEndotheliumDiseaseOxygen species
2017
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2017, 1-16. DOI: 10.1007/978-3-319-31420-4_41-1.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesRemodelingHemodynamic forcesEndotheliumDiseaseOxygen species
2013
A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia
Goodwin JE, Palmer M, Pashankar F, Tufro A, Moeckel G. A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia. Clinical Nephrology 2013, 82: 205-210. PMID: 23391318, PMCID: PMC6990651, DOI: 10.5414/cn107767.Peer-Reviewed Original ResearchConceptsStem cell transplantHematopoietic stem cell transplantCell transplantRenal insufficiencyKidney biopsyPediatric patientsNephrotic syndromeExtensive foot process effacementAbnormal lymphocyte responsesT-cell acute lymphoblastic leukemiaChronic kidney diseaseChronic interstitial nephritisAcute lymphoblastic leukemiaPre-conditioning regimensFoot process effacementHost diseaseImmunosuppressive therapyRenal failureInterstitial nephritisLymphocyte responsesCommon sequelaeInterstitial infiltratesProphylactic medicationKidney diseaseLikely multifactorial