microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney
Srivastava SP, Hedayat A, Kanasaki K, Goodwin JE. microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney. Frontiers In Pharmacology 2019, 10: 904. PMID: 31474862, PMCID: PMC6707424, DOI: 10.3389/fphar.2019.00904.Peer-Reviewed Original ResearchMesenchymal transitionExcess extracellular matrixDiverse biological processesGrowth factor β receptorNon-coding nucleotidesMiR-29Fibrotic disease statesRole of microRNAsEndothelial cell homeostasisEpithelial cellsMicroRNA biosynthesisMesenchymal programGrowth factor βAberrant regulationEndothelial cellsCrosstalk mechanismsCell homeostasisBiological processesM2 phenotype macrophagesDipeptidyl peptidase-4Extracellular matrixBone marrow-derived monocytesIntegrin β1Novel therapeutic targetMesenchymal activation