2020
Cardiovascular Imaging of Biology and Emotion
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. Cardiovascular Imaging of Biology and Emotion. Circulation Cardiovascular Imaging 2020, 13: e011054. PMID: 32762255, PMCID: PMC9261020, DOI: 10.1161/circimaging.120.011054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMental stressEpicardial coronary artery diseaseCoronary artery diseaseExercise-induced changesMicrovascular dysfunctionArtery diseaseObstructive diseaseClinical manifestationsVascular responsesCentral activationCardiovascular healthPathophysiologic changesCardiovascular responsesMyocardial ischemiaPeripheral vasculatureTreatment targetsVascular pathophysiologyPsychosocial determinantsCardiovascular imagingPsychosocial experiencesImplementation studyMS testingTriggers activationCardiovascular biologyDisease
2016
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production
Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCells, CulturedCoronary Artery DiseaseCoronary VesselsFemaleGenetic Predisposition to DiseaseHumansInflammation MediatorsInterleukin 1 Receptor Antagonist ProteinInterleukin-1betaMacrophagesMaleMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeuropeptidesPhenotypePlaque, AtheroscleroticPrognosisRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSignal TransductionTransfectionUp-RegulationVascular CalcificationConceptsCoronary calcium burdenIL-1β expressionCalcium burdenSerum IL-1β levelsElevated IL-1βIL-1β levelsCoronary artery diseaseInterleukin-1β expressionCalcified coronary arteryCardiovascular deathCardiovascular eventsArtery diseaseIndependent predictorsClinical outcomesVascular calcificationCoronary arteryIL-1βPlaque calciumAtherosclerotic calcificationExperimental atherogenesisInflammatory regulatorsMacrophage interleukinAtherosclerotic plaquesTherapeutic targetProgressive calcificationImaging Atherosclerotic Plaque Calcification: Translating Biology
Bailey G, Meadows J, Morrison AR. Imaging Atherosclerotic Plaque Calcification: Translating Biology. Current Atherosclerosis Reports 2016, 18: 51. PMID: 27339750, PMCID: PMC5206894, DOI: 10.1007/s11883-016-0601-6.Peer-Reviewed Original ResearchConceptsAtherosclerotic calcificationHard cardiovascular eventsTotal atherosclerotic burdenAtherosclerotic plaque calcificationAtherosclerotic burdenCardiovascular eventsCardiovascular mortalityCalcium burdenMyocardial infarctionMolecular imaging studiesPlaque calcificationAtherosclerotic lesionsImaging studiesMolecular imaging toolCalcificationGross assessmentPrecision medicineImaging toolMortalityBiologic processesBurdenInfarctionRisk assessment accuracyLesionsCalcium composition