2024
Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction.
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D'Onofrio G, Pilote L, Lichtman J. Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction. PLOS ONE 2024, 19: e0287949. PMID: 38277368, PMCID: PMC10817183, DOI: 10.1371/journal.pone.0287949.Peer-Reviewed Original ResearchConceptsMarital/partner statusPsychosocial factorsAcute myocardial infarctionYoung adultsHospital dischargeYear of hospital dischargeYoung acute myocardial infarctionAssociated with 1.3-foldCohort of young adultsLong-term readmissionCox proportional hazards modelsStatus interactionSimilar-aged menMyocardial infarctionProportional hazards modelUnpartnered statusPatient interviewsPhysician panelCardiovascular healthHospital readmissionSocioeconomic factorsAMI survivorsSequential adjustmentCardiac readmissionMultiple imputation
2023
Changes in Older Adult Trauma Quality When Evaluated Using Longer-Term Outcomes vs In-Hospital Mortality
Zogg C, Cooper Z, Peduzzi P, Falvey J, Castillo-Angeles M, Kodadek L, Staudenmayer K, Davis K, Tinetti M, Lichtman J. Changes in Older Adult Trauma Quality When Evaluated Using Longer-Term Outcomes vs In-Hospital Mortality. JAMA Surgery 2023, 158: e234856. PMID: 37792354, PMCID: PMC10551815, DOI: 10.1001/jamasurg.2023.4856.Peer-Reviewed Original ResearchConceptsHospital-level factorsTraumatic brain injurySevere traumatic brain injuryHospital mortalityTrauma QualityOlder adultsHip fractureComposite scoreHigher risk-adjusted oddsLevel 1 trauma centerIn-Hospital MortalityRisk-adjusted oddsLong-term outcomesMultivariable logistic regressionNontrauma centersTrauma patientsTerm outcomesTrauma centerPrimary diagnosisBrain injuryTrauma systemMAIN OUTCOMEMedicare feeService claimsForms of traumaSex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study
Gupta A, Barthel A, Mahajan S, Dreyer R, Yaggi H, Bueno H, Lichtman J, Krumholz H. Sex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study. Journal Of The American Heart Association 2023, 12: e027225. PMID: 37702090, PMCID: PMC10547292, DOI: 10.1161/jaha.122.027225.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAcute myocardial infarctionHigh OSA riskOSA riskSex-specific associationsFunctional outcomeHealth statusHigh riskVIRGO StudyMyocardial infarctionDepressive symptomsHistory of OSATime of AMIImpact of OSAObstructive sleep apnea riskLow-risk patientsSleep apnea riskMajority of patientsTime of presentationSex-specific outcomesWorse health statusHigh-risk menPoor health statusMental health statusPoor health outcomesImpact of Marital Stress on 1‐Year Health Outcomes Among Young Adults With Acute Myocardial Infarction
Zhu C, Dreyer R, Li F, Spatz E, Caraballo‐Cordovez C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D'Onofrio G, Pilote L, Lichtman J. Impact of Marital Stress on 1‐Year Health Outcomes Among Young Adults With Acute Myocardial Infarction. Journal Of The American Heart Association 2023, 12: e030031. PMID: 37589125, PMCID: PMC10547344, DOI: 10.1161/jaha.123.030031.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac-specific qualityGeneric health statusMyocardial infarctionBaseline healthMarital stressHealth outcomesHealth statusWorse patient-reported outcomesMental healthYoung adultsObservational cohort studyPatient-reported outcomesSocioeconomic factorsWorse mental healthReadmission 1Cause readmissionCohort studyYounger patientsRoutine screeningDepressive symptomsGreater oddsAnginaMale participantsOutcomesAssociation of short-term hospital-level outcome metrics with 1-year mortality and recurrence for US Medicare beneficiaries with ischemic stroke
Wang Y, Leifheit E, Goldstein L, Lichtman J. Association of short-term hospital-level outcome metrics with 1-year mortality and recurrence for US Medicare beneficiaries with ischemic stroke. PLOS ONE 2023, 18: e0289790. PMID: 37561680, PMCID: PMC10414659, DOI: 10.1371/journal.pone.0289790.Peer-Reviewed Original ResearchConceptsIschemic strokeInverse probability weightsStroke patientsCause mortalityOutcome metricsLower riskUS hospitalsBetter long-term outcomesRecurrent stroke rateIschemic stroke recurrenceIschemic stroke patientsLong-term outcomesUS Medicare beneficiariesPerformance categoriesIntermediate hospitalsRecurrent strokeStroke recurrenceCohort studyClinical factorsRecurrence ratePrincipal diagnosisPatient riskStroke rateReadmission measuresCox modelSex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac hospitalizationsSubdistribution HRYounger patientsMyocardial infarctionSex differencesYoung womenCause-specific hospitalizationsCause of hospitalizationWorse health statusSignificant sex disparityNoncardiovascular hospitalizationsVIRGO StudyIndex episodeAdverse outcomesIncidence rateHospitalizationHigh riskSex disparitiesHealth statusPatientsU.S. hospitalsWomenInfarctionOutcomesHigher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort
Gulanski B, Butera N, Krause-Steinrauf H, Lichtman J, Harindhanavudhi T, Green J, Suratt C, AbouAssi H, Desouza C, Ahmann A, Wexler D, Aroda V, Crandall J, McKee, Behringer-Massera S, Brown-Friday J, Xhori E, Ballentine-Cargill K, Duran S, Estrella H, de la torre S, Lukin J, Phillips L, Burgess E, Olson D, Rhee M, Wilson P, Raines T, Boers J, Costello J, Maher-Albertelli M, Mungara R, Savoye L, White C, Gullett C, Holloway L, Morehead F, Person S, Sibymon M, Tanukonda S, Adams C, Ross A, Balasubramanyam A, Gaba R, Hattery E, Ideozu A, Jimenez J, Montes G, Wright C, Hollander P, Roe E, Jackson A, Smiley A, Burt P, Estrada L, Chionh K, Ismail-Beigi F, Falck-Ytter C, Kassem L, Sood A, Tiktin M, Kulow T, Newman C, Stancil K, Cramer B, Iacoboni J, Kononets M, Sanders C, Tucker L, Werner A, Maxwell A, McPhee G, Patel C, Colosimo L, Krol A, Goland R, Pring J, Alfano L, Kringas P, Hausheer C, Tejada J, Gumpel K, Kirpitch A, Schneier H, Green J, AbouAssi H, Chatterjee R, Feinglos M, Jones J, Khan J, Zimmer R, Furst M, Satterwhite B, Thacker C, Kreider K, Mariash C, Mather K, Ismail H, Lteif A, Mullen M, Hamilton T, Patel N, Riera G, Jackson M, Pirics V, Aguillar D, Howard D, Hurt S, Bergenstal R, Carlson A, Martens T, Johnson M, Hill R, Hyatt J, Jensen C, Madden M, Martin D, Willis H, Konerza W, Yang S, Kleeberger K, Passi R, Fortmann S, Herson M, Mularski K, Glauber H, Prihoda J, Ash B, Carlson C, Ramey P, Schield E, Torgrimson-Ojerio B, Arnold K, Kauffman B, Panos E, Sahnow S, Bays K, Berame K, Cook J, Ghioni D, Gluth J, Schell K, Criscola J, Friason C, Jones S, Nazarov S, Barzilay J, Rassouli N, Puttnam R, Ojoawo B, Nelson R, Curtis M, Hollis B, Sanders-Jones C, Stokes K, El-Haqq Z, Kolli A, Tran T, Wexler D, Larkin M, Meigs J, Chambers B, Dushkin A, Rocchio G, Yepes M, Steiner B, Dulin H, Cayford M, Chu K, DeManbey A, Hillard M, Martin K, Thangthaeng N, Gurry L, Kochis R, Raymond E, Ripley V, Stevens C, Park J, Aroda V, Ghazi A, Magee M, Ressing A, Loveland A, Hamm M, Hurtado M, Kuhn A, Leger J, Manandhar L, Mwicigi F, Sanchez O, Young T, Garg R, Lagari-Libhaber V, Florez H, Valencia, Marks J, Casula S, Oropesa-Gonzalez L, Hue L, Cuadot A, Nieto-Martinez R, Veliz A, Gutt M, Kendal Y, Veciana B, Ahmann A, Aby-Daniel D, Joarder F, Morimoto V, Sprague C, Yamashita D, Cady N, Rivera-Eschright N, Kirchhoff P, Gomez B, Adducci J, Goncharova A, Hox S, Petrovitch H, Matwichyna M, Jenkins V, Broadwater L, Ishii R, Bermudez N, Hsia D, Cefalu W, Greenway F, Waguespack C, King E, Fry G, Dragg A, Gildersleeve B, Arceneaux J, Haynes N, Thomassie A, Pavlionis M, Bourgeois B, Hazlett C, Mudaliar S, Henry R, Boeder S, Pettus J, Diaz E, Garcia-Acosta D, Maggs S, DeLue C, Stallings A, Castro E, Hernandez S, Krakoff J, Curtis J, Killean T, Khalid M, Joshevama E, Diaz E, Martin D, Tsingine K, Karshner T, Albu J, Pi-Sunyer F, Frances S, Maggio C, Ellis E, Bastawrose J, Gong X, Banerji M, August P, Lee M, Lorber D, Brown N, Josephson D, Thomas L, Tsovian M, Cherian A, Jacobson M, Mishko M, Kirkman, Buse J, Dostou J, Machineni S, Young L, Bergamo K, Goley A, Kerr J, Largay J, Guarda S, Cuffee J, Culmer D, Fraser R, Almeida H, Coffer S, Debnam E, Kiker L, Morton S, Josey K, Fuller G, Garvey W, Cherrington A, Dyer D, Lawson M, Griffith O, Agne A, McCullars S, Cohen R, Craig J, Rogge M, Burton K, Kersey K, Wilson C, Lipp S, Meulen M, Adkins C, Onadeko T, Rasouli N, Baker C, Schroeder E, Razzaghi M, Lyon C, Penaloza R, Underkofler C, Lorch R, Douglass S, Steiner S, Sivitz W, Cline E, Knosp L, McConnell J, Lowe T, Herman W, Pop-Busui R, Tan M, Martin C, Waltje A, Katona A, Goodhall L, Eggleston R, Kuo S, Bojescu S, Bule S, Kessler N, LaSalle E, Whitley K, Seaquist E, Bantle A, Harindhanavudhi T, Kumar A, Redmon B, Bantle J, Coe M, Mech M, Taddese A, Lesne L, Smith S, Desouza C, Kuechenmeister L, Shivaswamy V, Burbach S, Rodriguez, Seipel K, Alfred A, Morales A, Eggert J, Lord G, Taylor W, Tillson R, Schade D, Adolphe A, Burge M, Duran-Valdez E, Martinez J, Bancroft A, Kunkel S, Ahmad F, McGinnis D, Pucchetti B, Scripsick E, Zamorano A, DeFronzo R, Cersosimo E, Abdul-Ghani M, Triplitt C, Juarez D, Garza R, Verastiqui H, Wright K, Puckett C, Raskin P, Rhee C, Abraham S, Jordan L, Sao S, Morton L, Smith O, Walker L, Schnurr-Breen L, Ayala R, Kreymer R, Sturgess D, Utzschneider K, Kahn, Wright L, Boyko E, Tsai E, Trence D, Trikudanathan S, Fattaleh B, Montgomery B, Atkinson K, Kozedub A, Concepcion T, Moak C, Prikhodko N, Rhothisen S, Elasy T, Martin S, Shackelford L, Goidel R, Hinkle N, Lovell C, Myers J, Hogan J, McGill J, Salam M, Schweiger T, Kissel S, Recklein C, Clifton M, Tamborlane W, Camp A, Gulanski B, Inzucchi, Pham K, Alguard M, Gatcomb P, Lessard K, Perez M, Iannone L, Montosa A, Magenheimer E, Cefalu W, Fradkin J, Burch H, Bremer A, Nathan D, Lachin J, Krause-Steinrauf H, Younes N, Bebu I, Butera N, Buys C, Fagan A, Gao Y, Ghosh A, Gramzinski, Hall S, Kazemi E, Legowski E, Liu H, Suratt C, Tripputi M, Arey A, Backman M, Bethepu J, Lund C, Dhaliwal P, McGee P, Mesimer E, Ngo L, Steffes M, Seegmiller J, Saenger A, Arends V, Gabrielson D, Conner T, Warren S, Day J, Huminik J, Scrymgeour A, Soliman E, Pokharel Y, Zhang Z, Campbell C, Hu J, Keasler L, Hensley S, Li Y, Mihalcea R, Min D, Perez-Rosas V, Prosser L, Resnicow K, Ye W, Shao H, Zhang P, Luchsinger J, Sanchez D, Assuras S, Groessl E, Sakha F, Chong H, Hillery N, Everett B, Abdouch I, Bahtiyar G, Brantley P, Broyles F, Canaris G, Copeland P, Craine J, Fein W, Gliwa A, Hope L, Lee, Meiners R, Meiners V, O’Neal H, Park J, Sacerdote A, Sledge E, Soni L, Steppel-Reznik J, Turchin A, Brooks-Worrell B, Hampe C, Palmer J, Shojaie A, Higgins J, Fischer L, Golden S, Gonzalez J, Naik A, Walker E, Lotenberg L, Gallivan J, Lim J, Tuncer D. Higher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort. BMJ Open Diabetes Research & Care 2023, 11: e003159. PMID: 37094945, PMCID: PMC10151943, DOI: 10.1136/bmjdrc-2022-003159.Peer-Reviewed Original ResearchConceptsBody mass indexRisk factorsSocioeconomic risk factorsCardiovascular diseaseGreater prevalenceContemporary cohortHigher mean body mass indexMean body mass indexType 2 diabetes mellitusBurden of CVDYoung womenBlood pressure targetsGlycemia Reduction ApproachesAngiotensin receptor blockersCardiometabolic risk factorsLow HDL cholesterolPowerful risk factorComparative effectiveness studiesGreater relative riskCross-sectional analysisMetformin monotherapyTarget LDLReceptor blockersPressure targetsSevere obesityAssociation of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction
Okafor C, Zhu C, Raparelli V, Murphy T, Arakaki A, D’Onofrio G, Tsang S, Smith M, Lichtman J, Spertus J, Pilote L, Dreyer R. Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction. JAMA Network Open 2023, 6: e2255843. PMID: 36787140, PMCID: PMC9929697, DOI: 10.1001/jamanetworkopen.2022.55843.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung adultsHospital readmissionBlack raceMyocardial infarctionRacial differencesCardiac factorsSociodemographic characteristicsBlack individualsOdds of readmissionObservational cohort studyMedical record abstractionRisk of readmissionWhite individualsAdults Aged 18Year of dischargePostdischarge readmissionVIRGO StudyCause readmissionCohort studyPrimary outcomeRecord abstractionMulticenter studyAged 18Male ratio
2012
30-Day Risk-Standardized Mortality and Readmission Rates After Ischemic Stroke in Critical Access Hospitals
Lichtman JH, Leifheit-Limson EC, Jones SB, Wang Y, Goldstein LB. 30-Day Risk-Standardized Mortality and Readmission Rates After Ischemic Stroke in Critical Access Hospitals. Stroke 2012, 43: 2741-2747. PMID: 22935397, PMCID: PMC3547601, DOI: 10.1161/strokeaha.112.665646.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesRisk-standardized readmission ratesAnnual hospital volumeIschemic strokeReadmission ratesHospital volumeVolume quartileHighest risk-standardized mortality ratesPoor short-term outcomeMedicare beneficiaries 65 yearsService Medicare beneficiaries 65 yearsHighest volume quartileHospital volume quartilesPrimary discharge diagnosisLow-volume hospitalsShort-term outcomesBeneficiaries 65 years
2011
30-Day Mortality and Readmission After Hemorrhagic Stroke Among Medicare Beneficiaries in Joint Commission Primary Stroke Center-Certified and Noncertified Hospitals
Lichtman JH, Jones SB, Leifheit-Limson EC, Wang Y, Goldstein LB. 30-Day Mortality and Readmission After Hemorrhagic Stroke Among Medicare Beneficiaries in Joint Commission Primary Stroke Center-Certified and Noncertified Hospitals. Stroke 2011, 42: 3387-3391. PMID: 22033986, PMCID: PMC3292255, DOI: 10.1161/strokeaha.111.622613.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhageIntracerebral hemorrhageReadmission ratesHemorrhagic strokeMedicare beneficiariesJoint Commission Primary Stroke CentersLower risk-adjusted mortality ratesCox proportional hazards regressionRisk-adjusted readmission ratesRisk-adjusted mortality ratesIschemic stroke patientsPrimary discharge diagnosisPrimary stroke centerProportional hazards regressionService Medicare beneficiariesEffects of careHospital mortalityStroke centersStroke patientsDischarge diagnosisHazards regressionMortality rateBetter outcomesHospitalPatientsOutcomes after ischemic stroke for hospitals with and without Joint Commission–certified primary stroke centers
Lichtman JH, Jones SB, Wang Y, Watanabe E, Leifheit-Limson E, Goldstein LB. Outcomes after ischemic stroke for hospitals with and without Joint Commission–certified primary stroke centers. Neurology 2011, 76: 1976-1982. PMID: 21543736, PMCID: PMC3109877, DOI: 10.1212/wnl.0b013e31821e54f3.Peer-Reviewed Original ResearchConceptsPrimary stroke centerRisk-standardized mortalityJoint CommissionPSC hospitalsIschemic strokeReadmission ratesStroke centersService Medicare beneficiariesHospital referral regionsIschemic stroke dischargesPSC certificationPatient demographicsComorbid conditionsStudy cohortMortality outcomesNational averagePrimary diagnosisReferral regionsMedicare beneficiariesHierarchical linear regression modelsHospitalStroke dischargesLinear regression modelsLower ratesStroke
2010
Use of Antithrombotic Medications Among Elderly Ischemic Stroke Patients
Lichtman JH, Naert L, Allen NB, Watanabe E, Jones SB, Barry LC, Bravata DM, Goldstein LB. Use of Antithrombotic Medications Among Elderly Ischemic Stroke Patients. Circulation Cardiovascular Quality And Outcomes 2010, 4: 30-38. PMID: 21098780, PMCID: PMC3073519, DOI: 10.1161/circoutcomes.109.850883.Peer-Reviewed Original ResearchConceptsDeep vein thrombosis prophylaxisElderly ischemic stroke patientsIschemic stroke patientsThrombosis prophylaxisAntithrombotic medicationSkilled nursing facilitiesEligible patientsAntithrombotic therapyIschemic strokeAtrial fibrillationStroke patientsNursing facilitiesPatients ages 85 yearsSecondary stroke preventionAge 85 yearsRates of receiptLow treatment ratesRate of treatmentAntiplatelet medicationsStroke preventionEffect of agePatient agePatient characteristicsAntiplatelet drugsMedicare feeVariation in Recovery
Lichtman JH, Lorenze NP, D'Onofrio G, Spertus JA, Lindau ST, Morgan TM, Herrin J, Bueno H, Mattera JA, Ridker PM, Krumholz HM. Variation in Recovery. Circulation Cardiovascular Quality And Outcomes 2010, 3: 684-693. PMID: 21081748, PMCID: PMC3064946, DOI: 10.1161/circoutcomes.109.928713.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI patientsAMI patientsYoung womenHeart diseaseSex differencesExcess mortality riskIschemic heart diseaseRisk stratification modelPsychosocial risk factorsYears of ageQuality of careComparison cohortPrognostic factorsPrognostic importanceAMI populationMyocardial infarctionRisk factorsObservational studyMortality riskHigh riskAMI eventsPatientsAge accountWomenTrends in One-Year Recurrent Ischemic Stroke among the Elderly in the USA: 1994–2002
Allen NB, Holford TR, Bracken MB, Goldstein LB, Howard G, Wang Y, Lichtman JH. Trends in One-Year Recurrent Ischemic Stroke among the Elderly in the USA: 1994–2002. Cerebrovascular Diseases 2010, 30: 525-532. PMID: 20881382, PMCID: PMC2978738, DOI: 10.1159/000319028.Peer-Reviewed Original ResearchThe Role of Social Support in Health Status and Depressive Symptoms After Acute Myocardial Infarction
Leifheit-Limson EC, Reid KJ, Kasl SV, Lin H, Jones PG, Buchanan DM, Parashar S, Peterson PN, Spertus JA, Lichtman JH. The Role of Social Support in Health Status and Depressive Symptoms After Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2010, 3: 143-150. PMID: 20160162, PMCID: PMC3016989, DOI: 10.1161/circoutcomes.109.899815.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina PectorisChi-Square DistributionDepressionEvidence-Based MedicineFemaleHealth StatusHealth Status IndicatorsHumansLinear ModelsMaleMiddle AgedMyocardial InfarctionPoisson DistributionProspective StudiesQuality of LifeRegistriesRisk AssessmentRisk FactorsSex FactorsSocial SupportTime FactorsUnited StatesWomen's HealthWomen's Health ServicesConceptsAcute myocardial infarctionLow social supportDisease-specific qualityDepressive symptomsMyocardial infarctionHealth statusPhysical functioningLower disease-specific qualitySocial supportBaseline health statusBaseline depressive symptomsWorse health statusRisk of anginaLower physical functioningMyocardial infarction recoverySex-stratified associationsLower mental functioningSex-stratified analysesMore depressive symptomsFirst yearClinical factorsProspective studyNonsignificant trendSymptomsInfarction
2009
Hospital Arrival Time and Intravenous t-PA Use in US Academic Medical Centers, 2001–2004
Lichtman JH, Watanabe E, Allen NB, Jones SB, Dostal J, Goldstein LB. Hospital Arrival Time and Intravenous t-PA Use in US Academic Medical Centers, 2001–2004. Stroke 2009, 40: 3845-3850. PMID: 19797697, DOI: 10.1161/strokeaha.109.562660.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedAged, 80 and overBlack or African AmericanBrain IschemiaEmergency Medical ServicesEmergency Service, HospitalFemaleHealth Services AccessibilityHumansInjections, IntravenousIntracranial ThrombosisMaleMiddle AgedQuality of Health CareSeverity of Illness IndexStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTransportation of PatientsUnited StatesWhite PeopleConceptsIschemic stroke patientsSymptom onsetT-PA useStroke patientsHospital arrivalIntravenous tissue-type plasminogen activatorConsecutive ischemic stroke patientsEarly hospital arrivalPercentage of patientsUS academic centersHospital arrival timeRisk-adjusted analysisMultivariate logistic regressionCare-seeking behaviorAcademic medical centerTissue-type plasminogen activatorClinical characteristicsSevere strokePatient characteristicsBlack patientsEmergency departmentMedical recordsHospital careMedical CenterLower oddsStroke Patient Outcomes in US Hospitals Before the Start of the Joint Commission Primary Stroke Center Certification Program
Lichtman JH, Allen NB, Wang Y, Watanabe E, Jones SB, Goldstein LB. Stroke Patient Outcomes in US Hospitals Before the Start of the Joint Commission Primary Stroke Center Certification Program. Stroke 2009, 40: 3574-3579. PMID: 19797179, PMCID: PMC2782858, DOI: 10.1161/strokeaha.109.561472.Peer-Reviewed Original ResearchConceptsPrimary stroke centerCross-sectional studyBetter outcomesJoint CommissionHospital mortalityStroke centersCox proportional hazards modelStroke center certificationStroke patient outcomesProportional hazards modelYears of ageHierarchical logistic regressionIschemic strokeCenter certificationPatient outcomesMedicare feeHazards modelUS hospitalsService beneficiariesHospitalLogistic regressionPatientsMortalityRisk adjustmentStudy sampleDiagnostic Evaluation for Patients with Ischemic Stroke: Are There Sex Differences?
Watanabe E, Allen NB, Dostal J, Sama D, Claus EB, Goldstein LB, Lichtman JH. Diagnostic Evaluation for Patients with Ischemic Stroke: Are There Sex Differences? Cerebrovascular Diseases 2009, 27: 450-455. PMID: 19295208, DOI: 10.1159/000209240.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsStroke patientsIschemic strokeAcademic hospitalDiagnostic evaluationConsecutive ischemic stroke patientsDiagnostic testsAcute coronary symptomsCarotid artery ultrasoundManagement of womenUS academic medical centersMultivariate logistic regressionUse of neuroimagingAcademic medical centerUS academic hospitalsSex-associated differencesSex differencesClinical factorsCoronary symptomsPotential confoundersMedical recordsCarotid arteryMedical CenterPatientsLogistic regressionElderly Women Have Lower Rates of Stroke, Cardiovascular Events, and Mortality After Hospitalization for Transient Ischemic Attack
Lichtman JH, Jones SB, Watanabe E, Allen NB, Wang Y, Howard VJ, Goldstein LB. Elderly Women Have Lower Rates of Stroke, Cardiovascular Events, and Mortality After Hospitalization for Transient Ischemic Attack. Stroke 2009, 40: 2116-2122. PMID: 19228857, PMCID: PMC2757938, DOI: 10.1161/strokeaha.108.543009.Peer-Reviewed Original ResearchConceptsTransient ischemic attackCoronary artery diseaseArtery diseaseIschemic attackCardiovascular eventsOutcomes 30 daysService Medicare patientsRisk-adjusted analysisProportional hazards modelYears of ageRandom effects logistic modelSex-related differencesSex-based differencesCardiac comorbiditiesTIA admissionsCause readmissionElderly patientsHospital dischargePrior hospitalizationBetter prognosisUnadjusted ratesMedical historyElderly womenMedicare patientsHazards modelThe joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction
Champney K, Frederick P, Bueno H, Parashar S, Foody J, Merz C, Canto J, Lichtman J, Vaccarino V, Investigators F. The joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction. Heart 2009, 95: 895. PMID: 19147625, PMCID: PMC3065924, DOI: 10.1136/hrt.2008.155804.Peer-Reviewed Original ResearchConceptsNon-ST elevation MIST-elevation MIElevation myocardial infarctionMyocardial infarctionNSTEMI patientsNon-ST elevation myocardial infarctionST-elevation myocardial infarctionRetrospective cohort studyExcess mortality riskShort-term mortalityAcute myocardial infarctionSex-related differencesHospital mortalityUnadjusted RRHospital deathCohort studyPatient ageExcess riskNational registryHospital participantsMAIN OUTCOMEMortality riskOlder womenAge 50Better survival