2014
Negative Blood Oxygen Level Dependent Signals During Speech Comprehension
Moreno D, Schiff ND, Hirsch J. Negative Blood Oxygen Level Dependent Signals During Speech Comprehension. Brain Connectivity 2014, 5: 232-244. PMID: 25412406, PMCID: PMC4432885, DOI: 10.1089/brain.2014.0272.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependent (BOLD) signalSpeech conditionsLevel-dependent signalBOLD signalSpeech comprehensionResting baselineNatural speechComprehension of speechCanonical language areasLanguage-related tasksNatural speech conditionNegative BOLD responseReceptive languageLanguage tasksPassive listeningComprehension studiesFrontoparietal regionsLanguage areasSame stimuliBOLD responseComprehensionBrain regionsSame speech
2013
Dynamic Coupling Between the Lateral Occipital-Cortex, Default-Mode, and Frontoparietal Networks During Bistable Perception
Karten A, Pantazatos SP, Khalil D, Zhang X, Hirsch J. Dynamic Coupling Between the Lateral Occipital-Cortex, Default-Mode, and Frontoparietal Networks During Bistable Perception. Brain Connectivity 2013, 3: 286-293. PMID: 23510237, PMCID: PMC3685318, DOI: 10.1089/brain.2012.0119.Peer-Reviewed Original Research
2011
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder
Schneier FR, Pomplun M, Sy M, Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research 2011, 194: 271-278. PMID: 22047726, PMCID: PMC3230304, DOI: 10.1016/j.pscychresns.2011.08.006.Peer-Reviewed Original ResearchConceptsParoxetine treatmentInferior parietal lobuleGeneralized social anxiety disorderNeural responsesPosterior cingulateParietal lobuleAnxiety disordersGSAD patientsEye contactMiddle occipital cortexMiddle frontal gyrusFunctional magnetic resonanceSymptomatic improvementHealthy comparison participantsOccipital cortexSocial anxiety disorderSymptom reductionAnterior cingulatePatientsUnmedicated adultsParahippocampal cortexNeural circuitrySupramarginal gyrusFrontal gyrusCingulateDistinct but overlapping neural networks subserve depression and insecure attachment
Galynker II, Yaseen ZS, Katz C, Zhang X, Jennings-Donovan G, Dashnaw S, Hirsch J, Mayberg H, Cohen LJ, Winston A. Distinct but overlapping neural networks subserve depression and insecure attachment. Social Cognitive And Affective Neuroscience 2011, 7: 896-908. PMID: 22037687, PMCID: PMC3501706, DOI: 10.1093/scan/nsr074.Peer-Reviewed Original ResearchConceptsSub-cortical activityBeck Depression InventoryEffect of depressionLevel-dependent responsesSub-cortical componentsCortico-striatoCortical effectsDepression scoresThalamic circuitsDepression InventoryCortical encodingDepressionFMRI scanningBrain activityNeural mechanismsPsychotherapeutic outcomeInsecure attachmentScoresSame circuitryFemale strangerMultiple linear regressionLater attachmentLinear regressionPatientsAttachment insecurity
2010
Self-face enhances processing of immediately preceding invisible faces
Pannese A, Hirsch J. Self-face enhances processing of immediately preceding invisible faces. Neuropsychologia 2010, 49: 564-573. PMID: 21168427, DOI: 10.1016/j.neuropsychologia.2010.12.019.Peer-Reviewed Original ResearchAdaptation, PhysiologicalAdultBrainCalibrationCuesData Interpretation, StatisticalDiscrimination, PsychologicalFaceFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetOxygenParietal LobePerceptual MaskingPhotic StimulationPsychomotor PerformanceReaction TimeRecognition, PsychologySex CharacteristicsVisual PerceptionYoung Adult
2009
Effects of heartbeat and respiration on macaque fMRI: Implications for functional connectivity
Teichert T, Grinband J, Hirsch J, Ferrera VP. Effects of heartbeat and respiration on macaque fMRI: Implications for functional connectivity. Neuropsychologia 2009, 48: 1886-1894. PMID: 19969009, PMCID: PMC2876227, DOI: 10.1016/j.neuropsychologia.2009.11.026.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFunctional connectivityRespiratory artifactsAnesthetized macaque monkeysMagnetic resonance imagingNon-human primatesAwake humansMacaque monkeysResonance imagingFalse negative correlationNeuronal energy consumptionEffect of heartbeatNegative correlationAdequate replacementRespiratory activityNeural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze
Schneier FR, Kent JM, Star A, Hirsch J. Neural circuitry of submissive behavior in social anxiety disorder: A preliminary study of response to direct eye gaze. Psychiatry Research 2009, 173: 248-250. PMID: 19628377, PMCID: PMC2745296, DOI: 10.1016/j.pscychresns.2008.06.004.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderEye gazeAnxiety disordersPathophysiology of SADSubmissive behaviorFunctional magnetic resonance imagingDirect eye gazeAverted gazeDirect gazeNeural responsesPrefrontal cortexSAD subjectsAnterior cingulateNeural circuitryNeural activityBrain regionsGazeMagnetic resonance imagingHealthy volunteersResonance imagingDisordersInsulaCingulateFearSignificant differencesNeural Mechanisms of Grief Regulation
Freed PJ, Yanagihara TK, Hirsch J, Mann JJ. Neural Mechanisms of Grief Regulation. Biological Psychiatry 2009, 66: 33-40. PMID: 19249748, PMCID: PMC2782609, DOI: 10.1016/j.biopsych.2009.01.019.Peer-Reviewed Original ResearchReperfusion normalizes motor activation patterns in large‐vessel disease
Chmayssani M, Lazar RM, Hirsch J, Marshall RS. Reperfusion normalizes motor activation patterns in large‐vessel disease. Annals Of Neurology 2009, 65: 203-208. PMID: 19259970, PMCID: PMC2653600, DOI: 10.1002/ana.21554.Peer-Reviewed Original ResearchConceptsMotor activation patternsVasomotor reactivityActivation patternsInterest analysisIpsilateral motor activationLarge vessel diseaseNormal neurological functionHealthy control subjectsHigh-grade stenosisBlood oxygen level-dependent (BOLD) signalNormal blood flowDynamic functional reorganizationLevel-dependent signalFunctional magnetic resonanceRepeated-measures analysisHemodynamic failureHemodynamic impairmentRevascularization proceduresIpsilateral hemisphereNeurological functionControl subjectsClinical consequencesBlood flowFunctional reorganizationSpontaneous resolution
2008
Comparison of contrast-response functions from multifocal visual-evoked potentials (mfVEPs) and functional MRI responses
Park JC, Zhang X, Ferrera J, Hirsch J, Hood DC. Comparison of contrast-response functions from multifocal visual-evoked potentials (mfVEPs) and functional MRI responses. Journal Of Vision 2008, 8: 8-8. PMID: 19146350, PMCID: PMC2987574, DOI: 10.1167/8.10.8.Peer-Reviewed Original ResearchConceptsBOLD fMRI responsesMultifocal visual-evoked potentialsContrast response functionsVisual-evoked potentialsFMRI responsesNeural activityFunctional MRI responsesBOLD fMRI signalMonocular mfVEPRetinotopic mapMRI responseV1 areaPattern stimuliBOLD responseFMRI signalsSame stimuliSubjectsResponseV1MfVEPStimuliMfVEPsCortexThe dynamics of deductive reasoning: An fMRI investigation
Rodriguez-Moreno D, Hirsch J. The dynamics of deductive reasoning: An fMRI investigation. Neuropsychologia 2008, 47: 949-961. PMID: 18835284, DOI: 10.1016/j.neuropsychologia.2008.08.030.Peer-Reviewed Original ResearchConceptsDeductive reasoningReasoning processParietal regionsEvent-related fMRISupramodal networkPrevious imaging studiesNeural correlatesFMRI investigationOccipital complexLanguage areasBilateral caudate nucleusInformation processingReasoningSecond premiseImaging studiesTraditional focusCaudate nucleusSubstantive differencesFMRISubsequent conclusionsTime courseScientific investigationPhilosophical discussionCorrelatesTime pointsNeural Integration of Top-Down Spatial and Feature-Based Information in Visual Search
Egner T, Monti JM, Trittschuh EH, Wieneke CA, Hirsch J, Mesulam M. Neural Integration of Top-Down Spatial and Feature-Based Information in Visual Search. Journal Of Neuroscience 2008, 28: 6141-6151. PMID: 18550756, PMCID: PMC6670545, DOI: 10.1523/jneurosci.1262-08.2008.Peer-Reviewed Original ResearchConceptsCue informationVisual searchActivation gainVisual search targetBlood oxygenation level-dependent (BOLD) responseSpatial cue informationLevel-dependent responsesSearch onsetDown biasingSpatial expectancyOculomotor planningIntraparietal sulcusSearch targetSalience mapBOLD responseSearch templateCingulate regionsNeural integrationTarget featuresHuman brainTarget locationSearch performanceLeptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli
Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli. Journal Of Clinical Investigation 2008, 118: 2583-2591. PMID: 18568078, PMCID: PMC2430499, DOI: 10.1172/jci35055.Peer-Reviewed Original ResearchConceptsMiddle frontal gyrusNeural activityFood cuesFrontal gyrusFood-related visual cuesWeight lossFood intakeWeight loss-induced changesVisual food cuesVisual food stimuliMiddle temporal gyrusRelative leptin deficiencyWeight-reduced stateDaily subcutaneous injectionsBody weight maintenanceCognitive controlFood stimuliTemporal gyrusVisual cuesLeptin deficiencyObese subjectsWeight maintenanceLingual gyrusClinical managementFunctional MRI
2006
A Neural Representation of Categorization Uncertainty in the Human Brain
Grinband J, Hirsch J, Ferrera VP. A Neural Representation of Categorization Uncertainty in the Human Brain. Neuron 2006, 49: 757-763. PMID: 16504950, DOI: 10.1016/j.neuron.2006.01.032.Peer-Reviewed Original ResearchConceptsCategorization uncertaintyEvent-related functional MRIFundamental cognitive functionFrontoparietal attention networkMedial frontal gyrusStimulus categorizationNeural representationParietal eye fieldsVisual objectsCategorical boundariesAnterior insulaFrontal gyrusCortical substratesAttention networkCognitive functionVentral striatumFunctional MRIPsychophysical functionsEye fieldBrain regionsHuman brainDorsomedial thalamusDiscrete categoriesInsulaThalamic network
2005
Where Memory Meets Attention: Neural Substrates of Negative Priming
Egner T, Hirsch J. Where Memory Meets Attention: Neural Substrates of Negative Priming. Journal Of Cognitive Neuroscience 2005, 17: 1774-1784. PMID: 16269113, DOI: 10.1162/089892905774589226.Peer-Reviewed Original ResearchConceptsEpisodic retrievalNegative primingStimulus featuresColor-naming Stroop taskRight dorsolateral prefrontal cortexEpisodic memory retrievalSelective attention performanceMemory retrieval functionsEvent-related fMRICurrent target stimulusSelective attention systemNegative priming effectDorsolateral prefrontal cortexStroop taskAttention systemDistractor stimuliMemory retrievalAttention performanceNeurophysiological predictionsTarget stimuliStimulus informationNeural substratesNeural responsesTheoretical accountsPriming effectFunctional Specialization within the Medial Frontal Gyrus for Perceptual Go/No-Go Decisions Based on What, When, and Where Related Information: An fMRI Study
Talati A, Hirsch J. Functional Specialization within the Medial Frontal Gyrus for Perceptual Go/No-Go Decisions Based on What, When, and Where Related Information: An fMRI Study. Journal Of Cognitive Neuroscience 2005, 17: 981-993. PMID: 16102231, DOI: 10.1162/0898929054475226.Peer-Reviewed Original Research