11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls
Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE. 11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls. Journal Of Nuclear Medicine 2009, 50: 382-389. PMID: 19223416, PMCID: PMC3629294, DOI: 10.2967/jnumed.108.054866.Peer-Reviewed Original ResearchConceptsBeta-cell massType 1 diabetesInsulin secretionVMAT2 bindingRenal cortexLong-Standing Type 1 DiabetesType 2 vesicular monoamine transporterFunctional binding capacityBinding capacityVesicular monoamine transporterInsulin secretion measurementsHealthy controlsHigh nonspecific bindingHealthy subjectsPatientsPreclinical experimentsControl valuesHuman pancreasDiabetesPancreasSecretion measurementsMonoamine transportersReference tissueCortexVMAT2