2009
Reperfusion normalizes motor activation patterns in large‐vessel disease
Chmayssani M, Lazar RM, Hirsch J, Marshall RS. Reperfusion normalizes motor activation patterns in large‐vessel disease. Annals Of Neurology 2009, 65: 203-208. PMID: 19259970, PMCID: PMC2653600, DOI: 10.1002/ana.21554.Peer-Reviewed Original ResearchConceptsMotor activation patternsVasomotor reactivityActivation patternsInterest analysisIpsilateral motor activationLarge vessel diseaseNormal neurological functionHealthy control subjectsHigh-grade stenosisBlood oxygen level-dependent (BOLD) signalNormal blood flowDynamic functional reorganizationLevel-dependent signalFunctional magnetic resonanceRepeated-measures analysisHemodynamic failureHemodynamic impairmentRevascularization proceduresIpsilateral hemisphereNeurological functionControl subjectsClinical consequencesBlood flowFunctional reorganizationSpontaneous resolution
2006
Hemodynamic Impairment as a Stimulus for Functional Brain Reorganization
Marshall RS, Krakauer JW, Matejovsky T, Zarahn E, Barnes A, Lazar RM, Hirsch J. Hemodynamic Impairment as a Stimulus for Functional Brain Reorganization. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 1256-1262. PMID: 16421509, DOI: 10.1038/sj.jcbfm.9600274.Peer-Reviewed Original ResearchConceptsVasomotor reactivityHemodynamic impairmentMotor-related activityControl subjectsFunctional reorganizationMotor regionsLevel-dependent signal intensityAbnormal cerebral hemodynamicsTypical motor activitiesLarge vessel occlusionSubgroup of patientsBlood oxygen level-dependent (BOLD) signal intensityContralateral motor areasFunctional brain reorganizationCarbon dioxide inhalationSimple motor taskFunctional magnetic resonanceAbnormal vasoreactivityTranscranial DopplerBrain reorganizationVessel occlusionCerebral hemodynamicsHand contralateralMotor areaFocal lesions