2007
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS
Mitsumoto H, Ulu A, Pullman S, Gooch C, Chan S, Tang M, Mao X, Hays A, Floyd A, Battista V, Montes J, Hayes S, Dashnaw S, Kaufmann P, Gordon P, Hirsch J, Levin B, Rowland L, Shungu D. Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology 2007, 68: 1402-1410. PMID: 17452585, DOI: 10.1212/01.wnl.0000260065.57832.87.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyotrophic Lateral SclerosisAspartic AcidBiomarkersCreatineDiffusion Magnetic Resonance ImagingFemaleFollow-Up StudiesHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMotor CortexMotor Neuron DiseaseMotor NeuronsMuscular Atrophy, SpinalNeural ConductionProspective StudiesTranscranial Magnetic StimulationConceptsMotor unit number estimationCentral motor conduction timeMotor conduction timeAcetyl-aspartate concentrationsUMN syndromeControl subjectsTibialis anteriorConduction timeObjective markersLower motor neuron dysfunctionLower motor neuron involvementALS Functional RatingMotor neuron involvementMotor neuron dysfunctionProton MR spectroscopic imagingTranscranial magnetic stimulationRatio of NAADiffusion tensor imagingLMN syndromesDisease activityNeuron involvementNeuron dysfunctionMR spectroscopic imagingFunctional ratingObjective biomarkers
2006
Structure-function relationships in the human visual system using DTI, fMRI and visual field testing: pre- and post-operative assessments in patients with anterior visual pathway compression.
Rosiene J, Liu X, Imielinska C, Ferrera J, Bruce J, Hirsch J, D'Ambrosio A. Structure-function relationships in the human visual system using DTI, fMRI and visual field testing: pre- and post-operative assessments in patients with anterior visual pathway compression. 2006, 119: 464-6. PMID: 16404100.Peer-Reviewed Original ResearchConceptsAnterior visual pathway compressionVisual pathway compressionDiffusion tensor imagingFunctional MRIVisual lossVisual recoveryFunctional visual deficitsLarge pituitary lesionsPostoperative visual recoveryProgressive visual lossSignificant visual lossVisual field testingPost-operative assessmentWhite matter projectionsDTI dataVisual field mappingSurgical resectionOptic chiasmPituitary lesionsOptic radiationVisual deficitsFunctional visionPatientsBrain structuresTensor imaging