2012
Gray Matter Abnormalities in Social Anxiety Disorder: Primary, Replication, and Specificity Studies
Talati A, Pantazatos SP, Schneier FR, Weissman MM, Hirsch J. Gray Matter Abnormalities in Social Anxiety Disorder: Primary, Replication, and Specificity Studies. Biological Psychiatry 2012, 73: 75-84. PMID: 22748614, PMCID: PMC3465490, DOI: 10.1016/j.biopsych.2012.05.022.Peer-Reviewed Original ResearchConceptsControl subjectsAnxiety disordersGray matter abnormalitiesHealthy control groupAge 30 yearsDSM-IV criteriaTotal intracranial volumeVoxel-based morphometryGray matter differencesMagnetic resonance imagingBilateral temporal poleLateral orbitofrontal cortexPanic disorder subjectsAngular cortexPD groupFunctional disturbancesNeuroanatomical abnormalitiesSocial anxiety disorderControl groupTemporal poleStructural abnormalitiesLifetime historyResonance imagingSAD groupIntracranial volume
2011
Speech Stimulation during Functional MR Imaging as a Potential Indicator of Autism
Lai G, Schneider HD, Schwarzenberger JC, Hirsch J. Speech Stimulation during Functional MR Imaging as a Potential Indicator of Autism. Radiology 2011, 260: 521-30. PMID: 21628495, DOI: 10.1148/radiol.11101576.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusControl subjectsSpeech stimulationFunctional MR imagingFunctional MR imaging activationFunctional magnetic resonanceAutistic subjectsMR imagingPrimary auditory cortexWilcoxon rank sum testInstitutional review boardMagnetic resonanceSpread of activityTwo-sample t-testRank sum testUnivariate general linear model analysisProspective studyMR evaluationAuditory cortexGeneral linear model analysisControl groupObjective indicatorsTemporal gyrusInformed consentReview board
2009
Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa
Mayer L, Klein DA, Black E, Attia E, Shen W, Mao X, Shungu DC, Punyanita M, Gallagher D, Wang J, Heymsfield SB, Hirsch J, Ginsberg HN, Walsh BT. Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa. American Journal Of Clinical Nutrition 2009, 90: 1132-1137. PMID: 19793856, PMCID: PMC2762154, DOI: 10.3945/ajcn.2009.27820.Peer-Reviewed Original ResearchConceptsAdipose tissue distributionAcute weight restorationControl subjectsWeight maintenanceWeight restorationAdipose tissueAnorexia nervosaTissue distributionControl womenVisceral adipose tissue distributionLong-term weight maintenanceAdult womenWhole-body magnetic resonanceHealthy control subjectsFemale control subjectsHealthy control womenIntermuscular adipose tissueCentral adiposity phenotypeHospital dischargeNormal weightBody compositionNormalization of weightBody image distortionPatientsTime pointsReperfusion normalizes motor activation patterns in large‐vessel disease
Chmayssani M, Lazar RM, Hirsch J, Marshall RS. Reperfusion normalizes motor activation patterns in large‐vessel disease. Annals Of Neurology 2009, 65: 203-208. PMID: 19259970, PMCID: PMC2653600, DOI: 10.1002/ana.21554.Peer-Reviewed Original ResearchConceptsMotor activation patternsVasomotor reactivityActivation patternsInterest analysisIpsilateral motor activationLarge vessel diseaseNormal neurological functionHealthy control subjectsHigh-grade stenosisBlood oxygen level-dependent (BOLD) signalNormal blood flowDynamic functional reorganizationLevel-dependent signalFunctional magnetic resonanceRepeated-measures analysisHemodynamic failureHemodynamic impairmentRevascularization proceduresIpsilateral hemisphereNeurological functionControl subjectsClinical consequencesBlood flowFunctional reorganizationSpontaneous resolution
2007
Quantitative objective markers for upper and lower motor neuron dysfunction in ALS
Mitsumoto H, Ulu A, Pullman S, Gooch C, Chan S, Tang M, Mao X, Hays A, Floyd A, Battista V, Montes J, Hayes S, Dashnaw S, Kaufmann P, Gordon P, Hirsch J, Levin B, Rowland L, Shungu D. Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology 2007, 68: 1402-1410. PMID: 17452585, DOI: 10.1212/01.wnl.0000260065.57832.87.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyotrophic Lateral SclerosisAspartic AcidBiomarkersCreatineDiffusion Magnetic Resonance ImagingFemaleFollow-Up StudiesHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMotor CortexMotor Neuron DiseaseMotor NeuronsMuscular Atrophy, SpinalNeural ConductionProspective StudiesTranscranial Magnetic StimulationConceptsMotor unit number estimationCentral motor conduction timeMotor conduction timeAcetyl-aspartate concentrationsUMN syndromeControl subjectsTibialis anteriorConduction timeObjective markersLower motor neuron dysfunctionLower motor neuron involvementALS Functional RatingMotor neuron involvementMotor neuron dysfunctionProton MR spectroscopic imagingTranscranial magnetic stimulationRatio of NAADiffusion tensor imagingLMN syndromesDisease activityNeuron involvementNeuron dysfunctionMR spectroscopic imagingFunctional ratingObjective biomarkers
2006
Hemodynamic Impairment as a Stimulus for Functional Brain Reorganization
Marshall RS, Krakauer JW, Matejovsky T, Zarahn E, Barnes A, Lazar RM, Hirsch J. Hemodynamic Impairment as a Stimulus for Functional Brain Reorganization. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 1256-1262. PMID: 16421509, DOI: 10.1038/sj.jcbfm.9600274.Peer-Reviewed Original ResearchConceptsVasomotor reactivityHemodynamic impairmentMotor-related activityControl subjectsFunctional reorganizationMotor regionsLevel-dependent signal intensityAbnormal cerebral hemodynamicsTypical motor activitiesLarge vessel occlusionSubgroup of patientsBlood oxygen level-dependent (BOLD) signal intensityContralateral motor areasFunctional brain reorganizationCarbon dioxide inhalationSimple motor taskFunctional magnetic resonanceAbnormal vasoreactivityTranscranial DopplerBrain reorganizationVessel occlusionCerebral hemodynamicsHand contralateralMotor areaFocal lesions