Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy
Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein HC, Murray AM, Sullivan M, Horowitz KR, Ding J, Marcovina S, Lovato LC, Lovato J, Margolis KL, O'Connor P, Lipkin EW, Hirsch J, Coker L, Maldjian J, Sunshine JL, Truwit C, Davatzikos C, Bryan RN, investigators F. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. The Lancet Neurology 2011, 10: 969-977. PMID: 21958949, PMCID: PMC3333485, DOI: 10.1016/s1474-4422(11)70188-0.Peer-Reviewed Original ResearchConceptsTotal brain volumeType 2 diabetesIntensive treatment groupIntensive treatmentStandard treatmentGlycaemic controlDSST scoresTreatment groupsBrain volumeDigit Symbol Substitution Test scoreHigher glycated hemoglobinIntensive glycaemic controlOpen-label substudyStandard glycaemic controlStandard treatment groupUS National HeartMonth outcome measuresSubset of participantsSignificant treatment differencesACCORD studyCardiovascular eventsCardiovascular riskIntensive glucoseBrain atrophyIntensive therapyBrain tissue volume changes following weight gain in adults with anorexia nervosa
Roberto CA, Mayer LE, Brickman AM, Barnes A, Muraskin J, Yeung L, Steffener J, Sy M, Hirsch J, Stern Y, Walsh BT. Brain tissue volume changes following weight gain in adults with anorexia nervosa. International Journal Of Eating Disorders 2011, 44: 406-411. PMID: 21661001, PMCID: PMC3816503, DOI: 10.1002/eat.20840.Peer-Reviewed Original ResearchConceptsShort-term weight restorationWeight restorationGray matterAnorexia nervosaCerebrospinal fluidWhite matterBrain tissue volume changesWM volumeBrain volume deficitsUnderweight patientsAdult patientsControl womenTissue volume changesBrain volumeVolume deficitsPatientsAdult womenWeight gainSignificant increaseNervosaBody massWomenDeficitsLow levelsRestoration