2017
HER2 signaling regulates HER2 localization and membrane retention
Jeong J, Kim W, Kim LK, VanHouten J, Wysolmerski JJ. HER2 signaling regulates HER2 localization and membrane retention. PLOS ONE 2017, 12: e0174849. PMID: 28369073, PMCID: PMC5378417, DOI: 10.1371/journal.pone.0174849.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisBreast NeoplasmsCalciumCell Line, TumorCell MembraneCell ProliferationErbB ReceptorsGene Knockdown TechniquesHumansIntracellular SpaceLapatinibPlasma Membrane Calcium-Transporting ATPasesQuinazolinesReceptor, ErbB-2Receptor, ErbB-3RNA, Small InterferingUbiquitinationConceptsMembrane protrusionsCell surfaceSpecific plasma membrane domainsPlasma membrane domainsReceptor tyrosine kinasesMembrane domainsErbB family membersErbB3/HER3Tyrosine kinaseGenetic knockdownHER2 ubiquitinationHER2/HER3PMCA2 expressionPharmacologic inhibitionUbiquitinationERBB2 geneHsp90HER2/EGFRCalcium pumpMembrane retentionInternalizationHuman breast cancerFamily membersHER3Expression
2010
PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer
VanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 11405-11410. PMID: 20534448, PMCID: PMC2895115, DOI: 10.1073/pnas.0911186107.Peer-Reviewed Original ResearchConceptsPMCA2 expressionBreast cancerT47D breast cancer cellsIntracellular calcium levelsBreast cancer progressionBreast cancer cellsEpithelial cell apoptosisPoor outcomeIntracellular calciumCalcium levelsMammary gland involutionCancer progressionCell apoptosisCancer cellsMammary involutionApoptosisGland involutionCancerMammary epithelial cell apoptosisOutcomesPMCA2Triggers apoptosisApical surfaceExpressionOverexpression
2001
Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas
VanHouten J, Asch H, Asch B. Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas. Oncogene 2001, 20: 5366-5372. PMID: 11536049, DOI: 10.1038/sj.onc.1204701.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernBlotting, WesternCloning, MolecularConcanavalin ADNA, ComplementaryEndoplasmic ReticulumExtracellular MatrixHumansMammary Neoplasms, AnimalMiceMice, Inbred BALB CMicroscopy, FluorescenceMicrotubulesMolecular Sequence DataOpen Reading FramesPhosphoric Monoester HydrolasesPrecipitin TestsProtein Structure, TertiaryRNA, MessengerTransfectionTumor Cells, CulturedConceptsN-terminal BTB domainMouse mammary epithelial cellsPlacental-specific genesMammary epithelial cellsKb ORFBTB domainKelch familyProtein bindsActin filamentsEndoplasmic reticulumMouse mammary tumorsBreast cell linesHuman breast cell linesExtracellular matrixProteinCell linesEpithelial cellsMalignant progressionTranscriptsCellular structureMicrofilamentsActinGrowth rateMammary tumorsExpression