2015
OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism
Ardeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J. OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism. Endocrinology 2015, 156: 2762-2773. PMID: 25961842, PMCID: PMC4511126, DOI: 10.1210/en.2015-1232.Peer-Reviewed Original ResearchConceptsBone lossOPG treatmentOsteoblast numberActivated B cells ligandLactational bone lossMaternal calcium homeostasisMaternal calcium metabolismMilk calcium levelsRapid bone lossDietary calcium intakeMaternal bone lossBone resorption rateMaternal hypocalcemiaRecombinant OPGCalcium intakeMaternal deathsOsteoprotegerin levelsMaternal skeletonBone turnoverDietary calciumCalcium metabolismOsteoclast numberBone massOsteoclast activityAnabolic response
2007
Weaning Triggers a Decrease in Receptor Activator of Nuclear Factor-κB Ligand Expression, Widespread Osteoclast Apoptosis, and Rapid Recovery of Bone Mass after Lactation in Mice
Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ. Weaning Triggers a Decrease in Receptor Activator of Nuclear Factor-κB Ligand Expression, Widespread Osteoclast Apoptosis, and Rapid Recovery of Bone Mass after Lactation in Mice. Endocrinology 2007, 148: 3875-3886. PMID: 17495007, DOI: 10.1210/en.2006-1467.Peer-Reviewed Original ResearchConceptsBone lossBone massBone turnoverReceptor activatorOsteoclast apoptosisRapid bone lossC-telopeptide levelsNumber of osteoclastsBone formation rateNuclear factor-kappaB ligand (RANKL) mRNANuclear factor-kappaB ligand (RANKL) expressionRapid recoveryLevels of osteocalcinCessation of lactationSkeletal anabolismPTH levelsCalcium metabolismBone resorptionBone histomorphometryBone microarchitectureCalcium levelsOsteoblast numberLigand expressionReciprocal decreaseBone recovery
2005
The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland
Ardeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 2005, 38: 787-793. PMID: 16377269, DOI: 10.1016/j.bone.2005.11.009.Peer-Reviewed Original ResearchConceptsCalcium-sensing receptorPTHrP productionMammary epithelial cellsMammary glandCalcium transportEpithelial cellsCalcium homeostasisParathyroid hormone-related proteinParathyroid hormone secretionProduction of PTHrPHormone-related proteinSystemic calcium homeostasisExtracellular calcium ionsTransepithelial calcium transportG protein-coupled receptorsHormone secretionParathyroid glandsBone massCalcium handlingRenal tubulesTransient lossGlandGenetic confirmationReceptorsSecretion
2004
Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation
VanHouten J, Dann P, Stewart A, Watson C, Pollak M, Karaplis A, Wysolmerski J. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. Journal Of Clinical Investigation 2004, 113: 492-492. DOI: 10.1172/jci19504c1.Peer-Reviewed Original Research
2003
Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation
VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation. Journal Of Clinical Investigation 2003, 112: 1429-1436. PMID: 14597768, PMCID: PMC228471, DOI: 10.1172/jci19504.Peer-Reviewed Original ResearchConceptsBone lossBone turnoverMammary epithelial cellsParathyroid hormone-related proteinMammary glandMammary-specific deletionPTHrP-knockout miceRapid bone lossEpithelial cellsDihydroxy vitamin DNegative calcium balanceHormone-related proteinPreserves bone massAbsence of PTHrPExpression of CreUrinary cAMPVitamin DBone resorptionLate pregnancyBone massPTHrP mRNACalcium balanceKnockout micePTHrP proteinMammary developmentLow Estrogen and High Parathyroid Hormone-Related Peptide Levels Contribute to Accelerated Bone Resorption and Bone Loss in Lactating Mice
VanHouten JN, Wysolmerski JJ. Low Estrogen and High Parathyroid Hormone-Related Peptide Levels Contribute to Accelerated Bone Resorption and Bone Loss in Lactating Mice. Endocrinology 2003, 144: 5521-5529. PMID: 14500568, DOI: 10.1210/en.2003-0892.Peer-Reviewed Original ResearchConceptsBone lossBone mineral densityBone resorptionMineral densityDual-energy X-ray absorptiometryBone resorption markersX-ray absorptiometryRegulation of calciumAge-matched virginsPamidronate treatmentPTHrP levelsResorption markersLow estrogenEstrogen deficiencyBone turnoverEstrogen levelsPregnant miceBone metabolismBone massPeptide levelsSkeletal metabolismTotal bodyBone volumeCalcium homeostasisBiochemical markers