2009
Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects
Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects. PLOS ONE 2009, 4: e4221. PMID: 19156209, PMCID: PMC2626248, DOI: 10.1371/journal.pone.0004221.Peer-Reviewed Original ResearchConceptsCardiovascular developmentMass spectrometry-based proteomicsSpectrometry-based proteomicsNormal cardiovascular developmentAdhesion/migrationHuman CHDsProteomic datasetsHeart developmentProtein clustersMurine embryosProtein pathwayMolecular pathwaysFunctional roleProteinEmbryonic survivalYolk sacProtein levelsIdentifies biomarkersCardiovascular defectsWestern blottingPathwayNovel avenuesEmbryosComplete understandingProtein biomarkers
1999
Nitric Oxide: A Clinically Important Amniotic Fluid Markerto Distinguish Between Intra-Amniotic Mycoplasma and Non-Mycoplasma Infections
Hsu C, Aversa K, Lu L, Meaddough E, Jones D, Bahado-Singh R, Copel J, Lee I. Nitric Oxide: A Clinically Important Amniotic Fluid Markerto Distinguish Between Intra-Amniotic Mycoplasma and Non-Mycoplasma Infections. American Journal Of Perinatology 1999, 16: 161-166. PMID: 10458527, DOI: 10.1055/s-2007-993851.Peer-Reviewed Original ResearchConceptsAmniotic fluid testsIntra-amniotic infectionInterleukin-6Mycoplasma infectionLeukocyte countFluid testsAmniotic fluid creatinine levelsAmniotic fluid glucose levelNitric oxide metabolite concentrationsPositive amniotic fluid cultureInterleukin-6 concentrationsManagement of patientsAmniotic fluid concentrationsAmniotic fluid leukocyte countsAmniotic fluid cultureClinical characteristicsCreatinine levelsPregnant womenClinical managementFluid cultureGlucose levelsClinical importanceUseful markerGriess reagentInfection
1998
Elevated amniotic fluid nitric oxide metabolites and interleukin-6 in intra-amniotic infection.
Hsu C, Meaddough E, Hong S, Aversa K, Lu L, Copel J. Elevated amniotic fluid nitric oxide metabolites and interleukin-6 in intra-amniotic infection. Reproductive Sciences 1998, 5: 21-4. PMID: 9501294, DOI: 10.1016/s1071-5576(97)00099-3.Peer-Reviewed Original ResearchConceptsAmniotic fluid nitric oxide metabolitesIntra-amniotic infectionNitric oxide metabolitesLeukocyte esterase activityIL-6Oxide metabolitesLeukocyte countInterleukin-6Glucose levelsRank correlation testAmniotic fluid creatinine levelsAmniotic fluid glucose levelAmniotic fluid IL-6Positive amniotic fluid cultureGram stainIL-6 levelsInterleukin-6 concentrationsIL-6 concentrationsAmniotic fluid leukocyte countsUseful clinical markerMann-Whitney U testEnzyme-linked immunosorbentAmniotic fluid cultureCreatinine levelsGestational ageDual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection
Hsu C, Meaddough E, Aversa K, Hong S, Lee I, Bahodo-Singh R, Lu L, Copel J. Dual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection. American Journal Of Perinatology 1998, 15: 683-687. PMID: 10333395, DOI: 10.1055/s-2007-999302.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionNitric oxide metabolitesPreterm labor patientsAmniotic fluid nitric oxide metabolitesProstaglandin E2Preterm laborLabor patientsNitric oxideIntraamniotic infectionAmniotic fluidAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid creatinineProinflammatory nitric oxidePro-inflammatory nitric oxideAmniotic fluid concentrationsAmniotic fluid levelsNitric oxide synthaseCyclo-oxygenase-2Amniotic fluid cultureEnzyme-linked immunoassayOxide metabolitesLeukocyte countFluid cultureOxide synthase
1997
Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3′,5′-monophosphate in pregnant women with intraamniotic infection
Hsu C, Aversa K, Meaddough E, Lee I, Copel J. Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3′,5′-monophosphate in pregnant women with intraamniotic infection. American Journal Of Obstetrics And Gynecology 1997, 177: 793-796. PMID: 9369821, DOI: 10.1016/s0002-9378(97)70270-9.Peer-Reviewed Original ResearchConceptsAmniotic fluid nitric oxide metabolitesNitric oxide metabolitesCyclic guanosine monophosphateIntraamniotic infectionOxide metabolitesPregnant womenLeukocyte esterase activityGuanosine monophosphateLeukocyte countAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid glucose concentrationCyclic guanosineCyclic guanosine monophosphate levelsAmniotic fluid levelsRupture of membranesAmniotic fluid Gram stainAmniotic fluid leukocyte countsGuanosine monophosphate levelsAmniotic fluid culturePanel of testsPreterm contractionsEndogenous nitriteFluid cultureFluid levels