1995
Successful in utero therapy of fetal heart block
Copel J, Buyon J, Kleinman C. Successful in utero therapy of fetal heart block. American Journal Of Obstetrics And Gynecology 1995, 173: 1384-1390. PMID: 7503173, DOI: 10.1016/0002-9378(95)90621-5.Peer-Reviewed Original ResearchConceptsComplete heart blockFetal heart blockHeart blockAntibody levelsCongenital complete heart blockHeart block patientsMaternal antibody levelsPositive antibody screenSimilar antibody levelsSecond-degree blockDegree of blockCardiac conduction systemFetal cardiac conduction systemConcurrent myocarditisGlucocorticoid therapyMaternal autoantibodiesBlock patientsMaternal antibodiesAntibody screenUtero therapyCord samplesCardiac contractilityRapid resolutionB antibodiesCardiac conduction
1994
Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block.
Buyon J, Waltuck J, Caldwell K, Crawford B, Slade S, Copel J, Chan E. Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block. The Journal Of Rheumatology 1994, 21: 1943-50. PMID: 7837164.Peer-Reviewed Original ResearchConceptsCongenital heart blockAnti-60Heart blockCirculation of neonatesRatios of maternalUmbilical cord levelsTotal IgG levelsMean ratioAnti-52Neonatal circulationCord levelIgG levelsMaternal antibodiesSerum levelsNeonatal levelsUnaffected pregnanciesControl groupPregnancyFetal tissuesSelective depletionAntibodiesAutoantibodiesIndirect evidenceGroupNeonates
1991
Perinatal outcome of fetal complete atrioventricular block: A multicenter experience
Schmidt K, Ulmer H, Silverman N, Kleinman C, Copel J. Perinatal outcome of fetal complete atrioventricular block: A multicenter experience. Journal Of The American College Of Cardiology 1991, 17: 1360-1366. PMID: 2016455, DOI: 10.1016/s0735-1097(10)80148-2.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Pacing, ArtificialFemaleFetal DiseasesHeart BlockHeart RateHumansMaternal-Fetal ExchangePregnancyPregnancy OutcomePrenatal DiagnosisUltrasonographyConceptsComplete atrioventricular blockBeats/minStructural heart defectsAtrial isomerismAtrioventricular blockVentricular rateAV blockAtrial rateHeart defectsFetal complete atrioventricular blockDiscordant AV connectionsLeft atrial isomerismConnective tissue diseaseNormal cardiac anatomySecond-degree blockComplete AV blockComplex structural heart defectsSlow atrial rateAntinuclear antibodiesPerinatal outcomesAV connectionsMulticenter experienceClinical courseNeonatal deathTissue disease